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ProteomicsMultiplexed proteome dynamics profiling of HSP90 inhibitor 17-AAG
Investigation of proteostatic effects of HSP90 inhibition by 17-AAG and differentiation of maturation state dependent HSP90 requirements of proteins.
ORGANISM(S): Homo sapiens (Human) 
2018-04-05 | PXD008633 | Pride
Hsp90 17-aag Mpdp 
ProteomicsMultiplexed proteome dynamics profiling of HSP90 inhibitor 17-AAG in T-cells
Investigation of proteostatic effects of HSP90 inhibition by 17-AAG and differentiation of maturation state dependent HSP90 requirements of proteins in resting T-cells.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008635 | Pride
Hsp90 17-aag Mpdp Primary t-cells 
TranscriptomicsMolecular Signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17-AAG, in breast cancer.
We have done transcriptional profiling of 17-AAG treated (24h, 48H) breast cancer cell lines to understand the mechanisms of the drug action and indicate novel set of pharmacodynamic biomarkers of the drug response as well as of resistance Two-condition experiment, Untreated vs. Treated sensitive c...
ORGANISM(S): Homo sapiens 
2010-10-11 | E-GEOD-23209 | biostudies-arrayexpress
ProteomicsExpression profiling of HSP90 inhibitor 17-AAG in anti-CD3 and anti-CD28 stimulated T-cells
Investigation of expression effects of HSP90 inhibition by 17-AAG of proteins in resting and activated T-cells.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008627 | Pride
Hsp90 Anti-cd28 Activated t-cells Resting t-cells 17-aag Primary t-cells Anti-cd3 
ProteomicsMultiplexed proteome dynamics profiling of HSP90 inhibitor 17-AAG in anti-CD3 and anti-CD28 stimulated T-cells
Investigation of proteostatic effects of HSP90 inhibition by 17-AAG and differentiation of maturation state dependent HSP90 requirements of proteins in activated T-cells.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008634 | Pride
Hsp90 Anti-cd28 Activated t-cells 17-aag Mpdp Primary t-cells Anti-cd3 
TranscriptomicsTranscription profiling by array of human breast cancer MCF-7 cells treated with 17-AAG
17-AAG treatment of MCF-7 Microarray

Files containing additional statistical analysis and data for meta-probesets are available on the FTP site for the experiment, in E-MTAB-339.additional.zip
ORGANISM(S): Homo sapiens 
2011-08-18 | E-MTAB-339 | biostudies-arrayexpress
GenomicsDrug combination of 17-AAG and Belinostat on MDA-MB-231 breast cancer cells
Drug combination of 17-AAG and Belinostat on MDA-MB-231 breast cancer cells
PRJNA533241 | ENA
TranscriptomicsExpression data from 17-AAG resistance cell line
Develop the 17-AAG resistance human lung cancer cell line and used microarrays to observe the gene alternnation
ORGANISM(S): Homo sapiens 
2017-01-11 | GSE93384 | GEO
UnknownAcquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells.
Not available
S-EPMC2652695 | biostudies-literature
TranscriptomicsExpression data from human colonic cancer cell line SW480 and its acquired 17-AAG resistance cell line SW480-R
Heat shock protein 90 (HSP90) is a molecular chaperone required for the stability and function of many proteins. The chaperoning of oncoproteins by HSP90 enhances survival, growth and invasive potential of cancer cells. HSP90 inhibitors are promising new anticancer agents, in which the benzoquinone ...
ORGANISM(S): Homo sapiens 
2015-03-14 | GSE66867 | GEO
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