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TranscriptomicsGlobal transcriptional analysis of mouse fibroblasts, chemically-induced neurons (neuron-like cells) from mouse fibroblasts and mouse primary cortical neurons by RNA-seq
Recently, direct reprogramming between divergent lineages has been achieved by introducing cell-fate-determining transcription factors. This progress may provide alternative cell resources for drug discovery and regenerative medicine. However, the genetic manipulation may limit the future applicatio...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-68715 | biostudies-arrayexpress
Proteomicshuman placenta LC-MS/MS
Hypertensive disorder in pregnancy (HDP) refers to a series of diseases that cause the hypertension during pregnancy, including HDP, preeclampsia (PE) and eclampsia. This study screens differentially expressed proteins of placenta tissues in PE cases using 2D LC-MS/MS quantitative proteomics strateg...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD006755 | Pride
Placenta tissue Preeclampsia Quantitative proteomics 
ProteomicsLysosomal-associated protein transmembrane 5, tubular senescence, and progression of CKD
After LAPTM5 was overexpressed in rat renal tubular epithelial cells (NRK52E), proteomic sequencing was performed to analyze aging and fibrosis protein changes.
ORGANISM(S): Rattus Rattus 
PXD052845 |
ProteomicsDual-omics reveals the different roles of α1 and β-adrenergic receptors in acute sympathetic stress-induced cardiac inflammation
Sympathetic overactivation under strong acute stresses triggers acute cardiovascular events including myocardial infarction (MI), sudden cardiac death, and stress cardiomyopathy. α1-ARs and β-ARs, two dominant subtypes of adrenergic receptors in the heart, play a significant role in the physiologica...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-19 | PXD036011 | Pride
Adrenergic receptor Cardiac inflammation Acute sympathetic stress Dual-omics 
ProteomicsQuantitative proteomic analysis of UUO-14d kidneys from Adamts18+/+ versus Adamts18−/− mice using label-free LC-MS/MS
This project aims to investigate the proteomic differences between Adamts18+/+ and Adamts18−/− mice in response to unilateral ureteral obstruction (UUO) for 14 days. Kidney tissues were collected from both genotypes and subjected to quantitative proteomic analysis using label-free LC-MS/MS-based tec...
ORGANISM(S): Mus Musculus 
PXD064042 |
ProteomicsMulti-Omics of Spinal Ependymal Tumor
We conducted a multi-omics analysis of 25 patients, comprising 8 with ependymoma, 10 with myxopapillary ependymoma, and 7 with subependymoma, to identify both shared and distinct genomic, transcriptional, and proteomic features among these subtypes.
ORGANISM(S): Homo Sapiens 
PXD056112 |
ProteomicsProteomics Profile of right ventricular remodeling at compensatory stage
Proteomics Profile of right ventricular remodeling at compensatory stage (both PAB and MCT models)
ORGANISM(S): Rattus Norvegicus 
PXD057041 |
ProteomicsA Tissue-Specific Atlas of Mouse N-Glycoproteome
In this study, we employed StrucGP to generate the first high-resolution and site-specific N- glycoproteomic atlas across 24 diverse mouse tissues. This comprehensive dataset provides an unprecedented insight into the tissue-specific landscape of N-glycosylation, revealing how distinct glycan struct...
ORGANISM(S): Mus Musculus 
PXD063701 |
ProteomicsSite-specific N-glycoproteomics of aging mouse uterus tissues for benchmarking the StrucGAP analysis platform
This project presents the site-specific N-glycoproteomics dataset of aging mouse uterus tissues used to demonstrate and validate StrucGAP, a modular and scalable downstream analysis platform for glycoproteomics. Uterine samples were collected from 2- and 12-month-old C57BL/6 female mice (n = 15 per ...
ORGANISM(S): Mus Musculus 
PXD063260 |
ProteomicsPSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation
MDA-MB-231 cells with expression of Flag-GPX4 were treated with IFNg. An immunoprecipitation assay was performed, and immunoprecipitates were subjected to masspec analysis.
ORGANISM(S): Homo Sapiens 
2025-03-01 | PXD061373 |
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