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ProteomicsThe Functions of Serine 687 Phosphorylation of Human DNA Polymerase eta in UV Damage Tolerance
DNA polymerase (pol) is a Y-family translesion synthesis polymerase that plays a key role in the cellular tolerance toward UV irradiation-induced DNA damage. Here, we identified, for the first time, the phosphorylation of serine 687 (S687), which islocated in the highly conserved nuclear localizati...
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD002946 | Pride
Translesion synthesis Cdk2 Dna polymerase eta 
ProteomicsThe role of IRAKM in IL-1β-treated adipocytes
Toll-like receptors/Interleukin-1 receptor (IL-1R) signaling plays an important role in High-fat diet (HFD)-induced adipose tissue dysfunction contributing to obesity-associated metabolic syndromes. Here, we show an unconventional IL-1R-IRAKM (IL-1R-associated kinase M)-Slc25a1 signaling axis in adi...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD031934 | Pride
Irakm Fatty acid synthesis Pgc1a acetylation Adipocytes Slc25a1 
UnknownProfiling gene promoter occupancy of Sox2 in two phenotypically distinct breast cancer cell subsets using chromatin immunoprecipitation and genome-wide promoter microarrays.

Introduction

Aberrant expression of the embryonic stem cell marker Sox2 has been reported in breast cancer (BC). We previously identified two phenotypically distinct BC cell subsets separated based on their differential response to a Sox2 transcription activity reporter, namely the reporter-...
S-EPMC4303205 | biostudies-literature
ProteomicsIL-33 stabilizes the transcription factor IRF1
Interleukin-33 (IL-33) functions both as a secreted cytokine and as a nuclear factor, with pleiotropic roles in tumor growth and immunity. Here, we explored its role in hepatocellular carcinoma (HCC) and identified that its nuclear function mediated a mechanism of immune escape.
ORGANISM(S): Homo Sapiens 
2022-12-28 | PXD039110 |
ProteomicsProteome of Klebsiella under different conditions
Changes in Klebsiella's own protein levels under different substrate treatment conditions
ORGANISM(S): Klebsiella Sp. Nccp 232 
2024-01-16 | PXD048590 |
ProteomicsProteomic and metabolomic signatures associated with the immune response in healthy individuals immunized with an inactivated SARS-CoV-2 vaccine
CoronaVac (Sinovac), an inactivated vaccine for SARS-CoV-2, has been widely used for immunization. However, analysis of the underlying molecular mechanisms driving CoronaVac-induced immunity is still limited. Here, we applied a systems biology approach to understand the mechanisms behind the adaptiv...
ORGANISM(S): Homo Sapiens 
2022-03-09 | PXD032127 |
ProteomicsSerum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis
Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis
ORGANISM(S): Homo Sapiens 
2024-03-04 | PXD050309 |
ProteomicsVessel-on-a-Chip Coupled Proteomics Reveal Pressure-Overload-Induced Vascular Remodeling
We developed a vessel-on-a-chip to mimic both physiological and pathological stretch, along with a mouse model of hypertension. We applied proteomics analysis to investigate the changes in vascular smooth muscle cells using the vessel-on-a-chip system and changes in hypertensive mice.
ORGANISM(S): Mus Musculus 
2024-11-08 | PXD057724 |
ProteomicsVAMP8 function reveals tight linkage between endocytic recycling and endocytosis
Clathrin-mediated endocytosis (CME) is a multistage process that involves the initiation and stabilization of clathrin-coated pits (CCPs) that invaginate and finally detach from the plasma membrane to form clathrin-coated vesicles (CCVs). Given that SNARE proteins are essential for downstream vesicl...
ORGANISM(S): Homo Sapiens 
2026-03-09 | PXD075425 |
ProteomicsSILAC experiments profiling of the proteome of WT and CobB KO E.coli
SILAC experiments profiling of the proteome of WT and CobB KO E.coli
ORGANISM(S): Escherichia Coli 
2021-12-11 | PXD030345 |
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