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Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the therapeutic response is highly heterogeneous. A potential mode of resistance is tumor-intrinsic mechanisms leading to an immunosuppressive tumor microenvironment. However, the underlying interactive network remains elusive...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD059275 | Pride
Tuberculosis (TB) remains a leading cause of illness and death globally. Type 2 diabetes (T2D) patients are more likely to become infected with Mycobacterium tuberculosis (M.tb). When they are infected, they are more likely to develop active TB disease and to present with more severe TB and those wh...
ORGANISM(S): Homo sapiens 
Cashmere is regarded as a specialty and luxury fiber due to its scarcity and high economic value. For fiber quality assessment, it is technically very challenging to distinguish and quantify the cashmere fiber from yak or wool fibers because of their highly similar physical appearance and substantial...
ORGANISM(S): Bos mutus grunniens (Wild yak) (Bos grunniens) Ovis aries Capra hircus (Goat) 
2018-10-25 | PXD003107 | Pride
Most proteogenomic approaches for mapping single amino acid polymorphisms (SAPs) require construction of a sample-specific database containing protein variants predicted from the next-generation sequencing (NGS) data. We present a new strategy for direct SAP detection without relying on NGS data. Am...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-04-18 | PXD003101 | Pride
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