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ProteomicsWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
The endosomal FYVE- and WD40-domain-containing protein WDFY2 has been assigned a function as tumor suppressor, but its functional mechanism has remained elusive. Here we have used confocal, widefield and super-resolution fluorescence microscopy to show that WDFY2 localizes to the base of retromer-co...
ORGANISM(S): Homo sapiens (Human) 
2019-07-02 | PXD013480 | Pride
Vamp3 Endosome Ptdins3p Cell invasion Recycling Wdfy2 
ProteomicsWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
The endosomal FYVE- and WD40-domain-containing protein WDFY2 has been assigned a function as tumor suppressor, but its functional mechanism has remained elusive. Here we have used confocal, widefield and super-resolution fluorescence microscopy to show that WDFY2 localizes to the base of retromer-co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-23 | MSV000084122 | MassIVE
UnknownP63 modulates the expression of the WDFY2 gene which is implicated in cancer regulation and limb development.
Not available
S-EPMC6914664 | biostudies-literature
GenomicsHomo sapiens
CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma
PRJNA280103 | ENA
UnknownThe WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis.
Not available
S-EPMC1567675 | biostudies-literature
UnknownPopulation-based genome-wide association study of cognitive decline in older adults free of dementia: identification of a novel locus for the attention domain.
Not available
S-EPMC6739197 | biostudies-literature
UnknownA Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder.
Not available
S-EPMC5751362 | biostudies-literature
OtherMicroRNA profiling identifies miR-2355-5p as a key modulator in Renal Cell Carcinoma tumor growth
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is one of the first truncal event in clear cell Renal Cell Carcinoma (ccRCC) tumorigenesis. Accumulation of the Hypoxia Induced Factors (HIFα) acquired from VHL loss can promote ccRCC tumorigenesis through regulating microRNAs (miRNA)...
ORGANISM(S): Homo sapiens 
2025-03-05 | GSE246950 | GEO
UnknownPhosphorylation of VAMP3 couples IL-6 exocytosis to dendritic cell activation.
Not available
S-EPMC12579954 | biostudies-literature
UnknownMicroRNA profiling identifies VHL/HIF-2α dependent miR-2355-5p as a key modulator of clear cell Renal cell carcinoma tumor growth.
Not available
S-EPMC11869434 | biostudies-literature
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