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TranscriptomicsLRH1 silencing inhibits human colon cancer growth.
This study was undertaken to better determine the function of LRH-1 (NR5A2) in the colorectal cancers (CRC) through inducible shRNA-mediated knockdown within well-established CRC cell line Caco-2 Our work is the first to demonstrate that silencing of LRH-1 in established human CRC cell lines impairs...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-64695 | biostudies-arrayexpress
TranscriptomicsThe role of unliganded thyroid hormone receptors (TRs) in human adipose derived stem cells (hADSC)
Analysis of change in transcriptosome after TRα or TRβ knockdown in hADSC. Analysis of effects of siRNA transfection (siCtrl, siTRα, siTRβ or siETV5) in hADSC at gene expression level.The hypothesis tested in the present study was that unliganded TRα and TRβ have distinctive roles in these cel...
ORGANISM(S): Homo sapiens 
2016-10-26 | E-GEOD-75692 | biostudies-arrayexpress
TranscriptomicsThe role of thyroid hormone receptors (TRs) in human adipose derived stem cells (hADSC), isolated from human adipose tissue collected during liposuction procedures
Analysis of change in transcriptional networking and disection of the TRalpha and TRbeta roles in hADSC, and during differentiation of hADSC towadrd different lineages. Total RNA was obtained from hADSC, and adipocytes, chondrocytes and osteoblasts differentiated from hADSC treated with triiodothyt...
ORGANISM(S): Homo sapiens 
2016-10-26 | E-GEOD-75433 | biostudies-arrayexpress
TranscriptomicsIdentical gene regulation patterns of triiodothyronine (T3) and selective thyroid hormone receptor modulator GC-1 [Illumina]
Synthetic selective thyroid hormone (TH) receptor (TR) modulators (STRMs) exhibit beneficial effects on dyslipidemias in animals and humans and reduce obesity, fatty liver and insulin resistance in preclinical animal models. STRMs differ from native THs in preferential binding to the TR? subtype ver...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32444 | biostudies-arrayexpress
TranscriptomicsIdentical gene regulation patterns of triiodothyronine (T3) and selective thyroid hormone receptor modulator GC-1 [Affymetrix]
Synthetic selective thyroid hormone (TH) receptor (TR) modulators (STRMs) exhibit beneficial effects on dyslipidemias in animals and humans and reduce obesity, fatty liver and insulin resistance in preclinical animal models. STRMs differ from native THs in preferential binding to the TRβ subtype ver...
ORGANISM(S): Homo sapiens 
2011-10-31 | E-GEOD-32443 | biostudies-arrayexpress
TranscriptomicsIdentical gene regulation patterns of triiodothyronine (T3) and selective thyroid hormone receptor modulator GC-1
This SuperSeries is composed of the following subset Series: GSE32443: Identical gene regulation patterns of triiodothyronine (T3) and selective thyroid hormone receptor modulator GC-1 [Affymetrix] GSE32444: Identical gene regulation patterns of triiodothyronine (T3) and selective thyroid hormone re...
ORGANISM(S): Homo sapiens 
2011-10-31 | E-GEOD-32445 | biostudies-arrayexpress
ProteomicsAn integrated model system to study biofilm-associated adaptation to antimicrobials and resistance evolution in Pseudomonas aeruginosa MPAO1
Using an integrated model system for reproducible growth of biofilms, a JPIAMR-funded consortium of researchers* studied the expressed proteome of P. aeruginosa strain MPAO1 under i) planktonic growth, and ii) biofilm formation conditions. The model system included, as a first step, the sequencing a...
ORGANISM(S): Pseudomonas aeruginosa 
2021-09-09 | PXD017122 | Pride
Comparative genomics Strain mpao1 Planktonic Biofilm Flow chamber Colistin Proteogenomics Shotgun proteomics Transposon sequencing Antibiotic resistance related proteins Genome sequencing Antimicrobials P. aeruginosa 
ProteomicsMetabolic changes in adaptation to biofilm growth by streptococcus pneumoniae
Comparative analyses of protein expression between log-phase planktonic and 1-day and 7-day biofilm cultures from Streptococcus pneumoniae representing nascent and late phase biofilm growth were performed using the proteomic approach iTRAQ
ORGANISM(S): Streptococcus pneumoniae SP14-BS69 
2014-09-10 | PXD001182 | Pride
Biofilm Streptococcus pneumoniae 
TranscriptomicsTranscription profiling of NIH3T3 cells treated with platelet-derived growth factor and Src kinase inhibitors to identify immediate early genes that are induced by PDGF through Src family kinases and other kinases.
This experiment was performed to identify immediate early genes that were induced by PDGF specifically through Src family kinases (SFKs), MEK1/2, or PI 3-K.
ORGANISM(S): Mus musculus 
2007-09-22 | E-GEOD-2196 | biostudies-arrayexpress
UnknownMicrobiome network traits in the rumen predict average daily gain in beef cattle under different backgrounding systems.
Not available
S-EPMC8961956 | biostudies-literature
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