Sort   by:  
 Page size 
TranscriptomicsEverolimus protects podocytes via stabilizing TUBB2B and DCDC2 expression
Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function. Recent studies implicate that immunosuppressive age...
ORGANISM(S): Homo sapiens 
2015-09-09 | E-GEOD-66107 | biostudies-arrayexpress
ProteomicsMulti-omics profiling of Müller cells in diabetic retinopathy identifies the glucocorticoid receptor as a master regulator of gliotic response
Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is thought to be primarily a microvascular complication of diabetes. As a central element of the retinal neurovascular unit, Müller cells, the major macroglia of the retina, are important for maintaining a healthy and f...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD045085 | Pride
Diabetic retinopathy Proteomic analysis Expression profiling Müller glia Mrna 
UnknownModeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer.
Not available
S-EPMC8136103 | biostudies-literature
TranscriptomicsBulk RNA-seq of murine G-MDSCs after co-culture with ILC2s and control G-MDSCs
This experiment aimed to characterize the transcriptional response of murine granulocytic myeloid-derived suppressor cells (G-MDSCs) upon interaction with group 2 innate lymphoid cells (ILC2s). G-MDSCs were isolated from the bone marrow of C57BL/6 mice, while ILC2s were induced in vivo by hydrodynam...
ORGANISM(S): Mus musculus 
2026-10-01 | E-MTAB-16286 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human cancer cell lines HCT116, T47D and A549 in 3D collagen I microenvironments compared to 2D cell culture
The behavior of cancer cells strongly relies on the properties of the extracellular microenvironment. The aim was to compare the whole transcriptome of three non-invasive cancer cell lines, HCT-116, A549 and T-47D, embedded in collagen I matrices in a time-dependent manner to standard two-dimensiona...
ORGANISM(S): Homo sapiens 
2026-07-31 | E-MTAB-16838 | biostudies-arrayexpress
ProteomicsMaintenance of β-cell identity through the transcription co-factors TBL1X and TBL1XR1
Diabetes occurs because of inadequate insulin secretion from pancreatic β-cells, relative to insulin requirements. One mechanism explaining β-cell malfunction in diabetes is their loss of identity, maintained by a series of well-defined transcription factors, which activate the transcription of β-ce...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-25 | PXD054677 | Pride
Transcriptional control Tbl1xr1 Cell identity Β-cells Differentiation Pax6 Tbl1x Insulin Diabetes 
TranscriptomicsSTAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence
Heart failure with preserved ejection fraction (HFpEF) accounts for half of heart failure cases and is characterised by reduced pericyte coverage. While the contributions of other cardiac cell types to HFpEF are well-studied, the role of pericytes remains less understood. Using murine single-nucleus...
ORGANISM(S): Homo sapiens 
2025-04-25 | E-MTAB-15019 | biostudies-arrayexpress
TranscriptomicsClonal hematopoiesis activates pro-calcific pathways in macrophages and promotes aortic valve stenosis
PBMCs of patients with AVS having TET2 mutations versus those with no known CHIP mutations were utilized for scRNA-seq
ORGANISM(S): Homo sapiens 
2025-10-22 | E-MTAB-15820 | biostudies-arrayexpress
Sort   by:  
 Page size