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ProteomicsComprehensive Metabolomic Profiling of Osteoarthritis Unraveling Sexually Dimorphic Patterns
Osteoarthritis (OA) is a chronic disease characterized by high morbidity, affecting multiple body systems and associated with systemic metabolic disorders. The clinical features of OA exhibit significant sexual dimorphism. However, the specific metabolic characteristics underlying this difference re...
ORGANISM(S): Human 
2024-12-11 | MSV000096636 | MassIVE
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
ProteomicsPrecipitation mediates the role of stochastic process in soil microbial community assembly
Precipitation change is often associated with climate warming, but its effects on soil microbial community assembly remain relatively underexplored. Traditionally, it is thought that increasing the magnitude of environmental changes will increase the importance of deterministic processes in communit...
ORGANISM(S): Uncultivated Soil Bacterium 
2020-12-13 | PXD023103 |
ProteomicsProteomics Profile of right ventricular remodeling at compensatory stage
Proteomics Profile of right ventricular remodeling at compensatory stage (both PAB and MCT models)
ORGANISM(S): Rattus Norvegicus 
2024-10-22 | PXD057041 |
ProteomicsAn exosome-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis
Exosomes, reflecting the live cellular state, hold promise for non-invasive disease detection. However, the significance of exosome cargos has been underestimated, particularly in the clinic, mainly due to the scarcity of exosome. Here, we present a "one-step" high-throughput microfluidic platform i...
ORGANISM(S): Homo Sapiens 
2024-07-04 | PXD053690 |
ProteomicsProteomic analysis of bone marrow-derived macrophages after Nano-IFNγ/Zole and GGPP incubation
We designed and prepared a bisphosphonate-mineralized Nano-IFNγ (Nano-IFNγ/Zole) to promote trans-differentiation of macrophages from the M2 to M1 type. Bisphosphonate in the Nano-IFNγ/Zole reduced lysosomal acidification by inhibiting isoprene modification of Rab family proteins, enhanced tumor ant...
ORGANISM(S): Mus Musculus 
2024-07-05 | PXD053688 |
ProteomicsCOVID-19 increases extracorporeal coagulation during hemodialysis through upregulation of vWF/FBNL5 signaling
Introduction: COVID-19 has been shown to increase the risk of extracorporeal coagulation during hemodialysis in patients, but the mechanism is unclear. This study aims to investigate the effect and mechanism of COVID-19 on the risk of extracorporeal coagulation during hemodialysis. Methods: A retro...
ORGANISM(S): Homo Sapiens 
2023-08-03 | PXD044377 |
ProteomicsER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs
ER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs
ORGANISM(S): Homo Sapiens 
2024-08-20 | PXD055020 |
ProteomicsIdentification of the methyl-CpG binding protein 2 (MeCP2) interacting proteins in the high molecular weight (HMW) extract prepared from the human HEK293T cells by immunoprecipitation coupled with mass spectrometry analysis
Identification of MeCP2 interacting proteins in HMW extract of HEK293T cells
ORGANISM(S): Homo Sapiens 
2021-08-30 | PXD021650 |
ProteomicsLISS enables immune evasion of colorectal cancers irrespective of MSI status
LISS enables immune evasion of colorectal cancers irrespective of MSI status
ORGANISM(S): Homo Sapiens 
2026-05-25 | PXD078805 |
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