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ProteomicsMetabolic characterization of two white-rot fungi in diverse cultivation environments reveals biotechnologically relevant biosynthetic pathways
Two white-rot fungi, Trametes versicolor and Gelatoporia subvermispora, were cultivated in different environments - agitation and static incubation modes and variations in the level of antioxidants - during the conversion of a lignin-related aromatic compound and cellobiose. Both incubation mode and...
ORGANISM(S): Gelatoporia Subvermispora (ncbitaxon:42742) Trametes Versicolor (ncbitaxon:5325) 
2024-08-05 | MSV000095519 | MassIVE
ProteomicsFucosylation of HLA-DRB1 regulates CD4+T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy: CD4+ T Cell Phosphoproteomics
Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also adverse events requiring cessation of treatment. In addition to ineffective patient stratification, efficacy is impaired by paucity of intratumoral immu...
ORGANISM(S): Homo sapiens (Human) 
2022-12-16 | PXD038065 | Pride
Phosphoproteomics Fucosylation Melanoma Cd4 t cells Immunotherapy 
ProteomicsFucosylation of HLA-DRB1 regulates CD4+T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy: Fucoproteomic profiling of CD4 T cells
Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also adverse events requiring cessation of treatment. In addition to ineffective patient stratification, efficacy is impaired by paucity of intratumoral immu...
ORGANISM(S): Homo sapiens (Human) 
2022-12-16 | PXD038636 | Pride
Melanoma Fucose Cd4 t cells Immunotherapy 
TranscriptomicsTranscriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue
Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of lipolysis has been studied in detail, the transcriptional determinants of WAT lipolytic activity remain still largely unexplored. Here we show that ...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-43658 | biostudies-arrayexpress
TranscriptomicsThe transient inactivation of the master cell cycle phosphatase Cdc14 causes genomic instability in diploid cells of Saccharomyces cerevisiae.
Genomic instability is a common feature found in cancer cells. Accordingly, many tumor suppressor genes identified in familiar cancer syndromes are involved in the maintenance of the stability of the genome during every cell division, and are commonly referred to as caretakers. Inactivating mutation...
ORGANISM(S): Saccharomyces cerevisiae 
2015-05-05 | E-GEOD-68530 | biostudies-arrayexpress
TranscriptomicsDevelopmental and metabolic plasticity of ripe Semillon grape berries in response to Botrytis cinerea during noble rot
Noble rot results from atypical infections of ripe grape berries by Botrytis cinerea. Unlike bunch rot, noble rot promotes favorable changes in grape berries and accumulation of secondary metabolites that enhance wine grape quality. Noble rot-infected berries of Sémillon, a white-skinned variety, w...
ORGANISM(S): Vitis vinifera 
2015-10-12 | E-GEOD-67932 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human separated leukocyte subsets in SLE and vasculitis
Objective: To optimize a strategy for identifying gene expression signatures differentiating SLE and anti-neutrophil cytoplasmic antibody-associated vasculitis that provide insight into the pathogenesis and identify biomarkers.
Methods: Forty four vasculitis patients, 13 SLE patients and 25 age...
ORGANISM(S): Homo sapiens 
2010-06-02 | E-MTAB-145 | biostudies-arrayexpress
UnknownT<sub>1</sub> and T<sub>2</sub> measurements of the neonatal brain at 7 T.
Not available
S-EPMC7617262 | biostudies-literature
ProteomicsDirect identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leukocyte antigens (HLA) on the surface of native tumor tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the mel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-01-30 | MSV000080517 | MassIVE
UnknownNovel Compound Heterozygous ZAP70 R37G A507T Mutations in Infant with Severe Immunodeficiency.
Not available
S-EPMC11804099 | biostudies-literature
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