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ProteomicsNegative regulation of Type I IFN signaling by phosphorylation of STAT2 on T387
The samples were derived from STAT2 IP experiments from human fibrosarcoma cells. This experiment involved the transfection of cells with a flag tagged STAT2 and the goal of these experiments is to identify STAT2 binding partners.
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005008 | Pride
Stat2 Phosphorylation 
ProteomicsQuantitative profiling of protein sulfhydrome by the BTA-TMT
The redox-based modification of cysteine residues in proteins regulates their function in many biological processes. The gas molecule H2S has been shown to sulfhydrate redox sensitive cysteine residues resulting in an H2S-modified proteome known as the sulfhydrome. Tandem Mass Tags (TMT) multiplexin...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2020-03-09 | PXD015307 | Pride
Tmt Cysteine sulfhydration 
ProteomicsInhibition of KDEL receptors remodels the tumor microenvironment for T cell independent tumor regression
Tumor immunotherapy is supported by low-grade inflammatory conditions at the microenvironment, triggered by immunogenic cell death (ICD). However, ICD is dampened when tumors acquire resistance, affecting immune recognition. KDEL receptors (KDELRs), through a retrograde Golgi-to-ER transport, preven...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD072994 | Pride
Kdel protein Er stress Tumor microenvironment 
ProteomicsA novel strategy to characterize the pattern of β-lactam antibiotic-induced drug resistance in Acinetobacter baumannii.
Carbapenem-resistant Acinetobacter baumannii (CRAb) is an urgent public health threat, according to the CDC. This pathogen has few treatment options and causes severe nosocomial infections with >50% fatality rate. Although previous studies have examined the proteome of CRAb, there have been no focus...
ORGANISM(S): Acinetobacter baumannii A424 Bacteria 
2023-07-20 | PXD042336 | Pride
Tims tof pro2 Acinetobacter baumannii Dda lfq 
ProteomicsNovel Mechanism and Therapy of Anthracycline-Induced Cardiotoxicity (AIC)
Anthracyclines are potent chemotherapeutic agents known for their efficacy in treating various cancers via inhibition of topoisomerase II alpha (TOP2A). However, their clinical use is limited due to cardiotoxicity, primarily attributed to off-target inhibition of topoisomerase II beta (TOP2B) in car...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-05 | PXD077277 | Pride
Top2b Smyd1 
ProteomicsLRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses
Cancer immunotherapies boost antitumor immunity and improve the survival of cancer patients. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an immune 20 checkpoint target but presents elusive signaling mechanisms. We report a novel VISTA binding partner, Leucine-Rich Repeats and ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050084 | Pride
Bottom up proteomics Proximity labelling Cancer 
ProteomicsElucidating PTEN Conformational Dynamics and Phosphatase Regulation via Integrative Modeling and Mutation Prediction
PTEN (Phosphatase and TENsin homolog deleted on chromosome ten) is a major tumor suppressor gene that is frequently mutated or lost under cancerous conditions. PTEN is a dual-specificity phosphatase that negatively regulates the PI3K/AKT/mTOR signaling pathway at the plasma membrane (PM). Its functi...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD059974 | Pride
Molecular dynamics Molecular modeling Molecular biology Conformational change Rasp stability prediction Crosslinking mass spectrometry (xl-ms) Alphamissense Clinical mutation Integrative structural modeling Phosphatase and tensin homolog (pten) 
ProteomicsProteomics of Primary Uveal Melanoma:Insights to Metastasis and Protein Biomarkers
Uveal melanoma metastases are lethal and remain incurable. Quantitative proteomic analysis of 53 metastasizing and 47 non-metastasizing primary uveal melanoma (pUM) was pursued for insights into UM metastasis and protein biomarkers. The metastatic status of the pUM specimens was defined based on cli...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-15 | MSV000087437 | MassIVE
ProteomicsElucidating PTEN Conformational Dynamics and Phosphatase Regulation via Integrative Modeling and Mutation Prediction
PTEN-WT and PTEN-4A models generation using Rosetta restrained with XL-MS crosslink distance restraints. Two major conformations of each protein were modeled
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD060469 | Pride
Molecular dynamics Molecular modeling Molecular biology Conformational change Rasp stability prediction Crosslinking mass spectrometry (xl-ms) Alphamissense Clinical mutation Integrative structural modeling Phosphatase and tensin homolog (pten) 
ProteomicsElaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates
Approaches for the discovery of molecular glues remain limited. Here we report a phenotypic screening approach in which cytotoxins whose mechanisms require ubiquitination show gain of viability following pharmacological inhibition of the Ubiquitin-life modifier activating enzyme (UBA1/UAE). This a...
ORGANISM(S): Homo sapiens (Human) 
2025-06-17 | PXD062839 | Pride
Nucleoporin Targeted protein degradation Molecular glue degraders Protac 
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