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ProteomicsHuman WIPI interactome (LC-MSMS)
Analysis of the WIPI protein interactome using nanoLC-MS/MS analysis upon the immunopurification of GFP-tagged WIPI1, WIPI2B, WIPI2D, WIPI3, WIPI4 and GFP alone from U2OS cells. Prior to immunopurifications, cells were either kept under fed (DMEM/FCS) or starved conditions (EBSS), or were treated wi...
ORGANISM(S): Homo sapiens (Human) 
2017-06-01 | PXD006119 | Pride
Wipi2 Lc-msms Autophagy Wipi1 Wipi4 Wipi3 
UnknownLoss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis.
Not available
S-EPMC11021183 | biostudies-literature
UnknownThe rod-shaped ATG2A-WIPI4 complex tethers membranes in vitro.
Not available
S-EPMC6372110 | biostudies-literature
UnknownInsights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex.
Not available
S-EPMC6196511 | biostudies-literature
UnknownWIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.
Not available
S-EPMC5460038 | biostudies-literature
ProteomicsStructural basis for lipid transfer by the ATG2A-ATG9A complex
Autophagy is characterized by the formation of double-membrane vesicles called autophagosomes. ATG2A and ATG9A play an essential role in autophagy by mediating lipid transfer and re-equilibration between membranes for autophagosome formation. Here we report the cryo-EM structures of human ATG2A-WIPI...
ORGANISM(S): Homo sapiens (Human) 
2024-08-17 | PXD048906 | Pride
Lc-ms Xl-ms Autophagy 
UnknownA conserved ATG2 binding site in WIPI4 and yeast Hsv2 is disrupted by mutations causing β-propeller protein-associated neurodegeneration.
Not available
S-EPMC8682751 | biostudies-literature
UnknownA Dictyostelium model for BPAN disease reveals a functional relationship between the WDR45/WIPI4 homolog Wdr45l and Vmp1 in the regulation of autophagy-associated PtdIns3P and ER stress.
Not available
S-EPMC9037511 | biostudies-literature
UnknownComprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration.
Not available
S-EPMC10407718 | biostudies-literature
UnknownA conserved ATG2-GABARAP family interaction is critical for phagophore formation.
Not available
S-EPMC7054675 | biostudies-literature
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