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Alcohol consumption leads to formation of phosphatidylethanol (PEth) via the transphosphatidylation activity of phospholipase D (PLD) enzymes. Though this non-natural phospholipid routinely serves as a biomarker of chronic alcoholism, its pathophysiological roles remain unknown. We use a minimalist ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD029749 | Pride
Global quantitative proteomics of cells treated with the immunomodulatory drug pomalidomide or dipeptide degrons; global quantitative proteomics of cells treated with heterobifunctional degraders embedded with thalidomide or cyclic imide degrons; gloabl quantitative proteomics of red blood cells to ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-28 | PXD025413 | Pride
We identify cyclic imides, previously overlooked post-translation modifications, across different tissues (red blood cells and bovine lens) and human-derived cell lines and found that these modifications are globally regulated by cereblon.
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-07-28 | PXD030091 | Pride
The E3 ligase factor cereblon (CRBN) is a target of thalidomide and lenalidomide, which are therapeutic agents used in the treatment of hematopoietic malignancies and as ligands for targeted protein degradation. These agents are proposed to mimic a naturally occurring degron; however, the structural...
ORGANISM(S): Homo sapiens (Human) 
2022-07-28 | PXD034248 | Pride
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