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ProteomicsTargeted Quantitative Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins Revealed Potential Crosstalk between N6-Methyladenosine and Other RNA Modifications
N⁶-methyladenosine (m6A) and its reader, writer, and eraser (RWE) proteins assume crucial roles in regulating the splicing, stability, and translation of mRNA. To our knowledge, no systematic investigations have been conducted about the crosstalk between m6A and other modified nucleosides in RNA. He...
ORGANISM(S): Homo sapiens (Human) 
2022-09-24 | PXD036032 | Pride
Lc-prm N6-methyladenosine Epitranscriptomic reader Writer and eraser proteins 
ProteomicsTargeted Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins in Radioresistant Breast Cancer Cells
Epitransciptomic reader, writer and eraser (RWE) proteins recognize, install, and remove modified nucleosides in RNA, which are known to play essential roles in RNA processing, splicing, and stability. Here, we established a liquid chromatography–parallel reaction monitoring (LC-PRM) method for high...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD030387 | Pride
Epitransciptomic reader Lc-prm Radioresistant breast cancer Trmt1 Writer and eraser (rwe) proteins 
ProteomicsTargeted Quantitative Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins in Colorectal Cancer Metastasis
Epitranscriptomic reader, writer and eraser (RWE) proteins are involved in the recognition, installation, and removal, respectively, of chemical modifications in RNA, and aberrant expressions of some of these proteins were found to be associated with cancer initiation and progression. Here, we our r...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD030907 | Pride
Epitranscriptomic reader Prm Colorectal cancer metastasis Writer and eraser proteins 
GenomicsAmelioration of Brain Histone Methylopathies by Balancing a Writer-Eraser Duo KMT2A-KDM5C [RNA-seq]
Amelioration of Brain Histone Methylopathies by Balancing a Writer-Eraser Duo KMT2A-KDM5C [RNA-seq]
PRJNA525106 | ENA
GenomicsAmelioration of Brain Histone Methylopathies by Balancing a Writer-Eraser Duo KMT2A-KDM5C [ChIP-seq]
Amelioration of Brain Histone Methylopathies by Balancing a Writer-Eraser Duo KMT2A-KDM5C [ChIP-seq]
PRJNA525450 | ENA
ProteomicsTemporal Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins during Osteogenic Differentiation of Human Embryonic Stem Cells
Osteogenesis is the process of bone formation and is modulated by multiple regulatory networks. With the rapid development of the epitranscriptomics field, RNA modifications and their reader, writer, and eraser (RWE) proteins are shown to be involved in the regulation of various biological processes...
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD039249 | Pride
Epitranscriptomic reader Writer and eraser Osteogenesis 
GenomicsAmelioration of Brain Histone Methylopathies by Balancing a Writer-Eraser Duo KMT2A-KDM5C [ChIP-seq]
We describe a methyl histone writer-eraser double-mutant animal that corrects phenotypes of single-mutants KMT2A and KDM5C.
ORGANISM(S): Mus musculus 
2020-06-16 | GSE127817 | GEO
TranscriptomicsAmelioration of Brain Histone Methylopathies by Balancing a Writer-Eraser Duo KMT2A-KDM5C [RNA-seq]
We describe a methyl histone writer-eraser double-mutant animal that corrects phenotypes of single-mutants KMT2A and KDM5C.
ORGANISM(S): Mus musculus 
2020-06-16 | GSE127722 | GEO
UnknownCorrelated duplications and losses in the evolution of palmitoylation writer and eraser families.
Not available
S-EPMC5359973 | biostudies-literature
UnknownTargeted Quantitative Profiling of Epitranscriptomic Reader, Writer, and Eraser Proteins Using Stable Isotope-Labeled Peptides.
Not available
S-EPMC9867940 | biostudies-literature
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