Sort   by:  
 Page size 
ProteomicsSaccharomyces cerevisiae LC-MSMS
IP-MS detection of proteins pulled down by Glc7-FLAG by mass spectrometry
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-24 | PXD036005 | Pride
Lc-msms Saccharomyces cerevisiae 
ProteomicsGlucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation
We discovered that glucose directly bind to DDX21, induced the conformation change of the proteins and inhibit its helicase activity. Glucose also inhibits the dimerization of DDX21, re-localize DDX21 from nucleolus to nucleoplasm and reassemble DDX21 to RNA splicing complex. DDX21 is essential for ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD028561 | Pride
Proximity labeling Ddx21 Splicing Glucose Bioid Epidermal differentiation 
ProteomicsIP-MS detected the interation protein with PKM2
Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular diseases in ageing population. Although ECs rely glycolysis for energy production, little is known about the role of glycolysis in ECs senescence. Here, we report a critical role for glycolysis-derived serine ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD035585 | Pride
Co-immunoprecipitation Pkm2 
ProteomicsIP-MS detected the interation proteins of PHGDH
Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular diseases in ageing population. Although ECs rely glycolysis for energy production, little is known about the role of glycolysis in ECs senescence. Here, we report a critical role for glycolysis-derived serine ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD035586 | Pride
Mass spectrometry Phgdh Co-immunoprecipitation 
Sort   by:  
 Page size