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ProteomicsReduced PRC2 function causes asparaginase resistance in T-ALL by decreasing WNT pathway activity
Loss-of-function mutations and deletions in the core components of the epigenetic polycomb repressive complex 2 (PRC2) are associated with poor initial treatment response in T-cell acute lymphoblastic leukemia (T-ALL), but the mechanisms that underpin resistance to individual therapies are unknown. ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-23 | PXD045010 | Pride
ProteomicsA NOVEL REGULATION OF FUMARATE HYDRATASE ACTIVITY THROUGH HISTONE DEACETYLASE 6 BINDING
Introduction: Altered metabolism is a key hallmark of tumour cells (Pavlova & Thompson, 2016) and has long been associated with relapse and resistance to treatment (Gonçalves et al., 2021; Lv et al., 2022). Recently, we identified a new role for histone deacetylase 6 (HDAC6) in the regulation of gl...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD057865 | Pride
Fumarate hydratase Regulation Histone deacetylase 6. 
ProteomicsTemporal (phospho-)proteomic profiling of neurotrophic receptor tyrosine kinase signalling in neuroblastoma cells
Neurotrophic receptor tyrosine kinases, also known as Tropomyosin receptor kinases (TrkA, TrkB and TrkC), despite their homology, contribute to the clinical heterogeneity of childhood cancer neuroblastoma. TrkA expression is associated with low-stage disease and is often seen with spontaneous tumour...
ORGANISM(S): Homo sapiens (Human) 
2024-08-29 | PXD054441 | Pride
Neuroblastoma Trk Phosphoproteome Proteome 
ProteomicsInteractome dynamics of RAF1-BRAF kinase monomers and dimers
RAF kinases play major roles in cancer. BRAFV600E mutants drive ~6% of human cancers. Potent kinase inhibitors exist but show variable effects in different cancer types, sometimes even inducing paradoxical RAF kinase activation. Both paradoxical activation and drug resistance are frequently due to e...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD036792 | Pride
Raf1 Braf Dimerization Raf kinase Interactome 
ProteomicsPhosphoproteomics of TrkA and TrkB signaling in SH-SY5Y neuroblastoma cells
Human neuroblastoma cells (SH-SY5Y) were engineered to have stable expression of either TrkA (NTRK1) or TrkB (NTRK2) receptors. The cells were pretreated with 0.5 μM Trametinib, 2.5 μM Gefitinib, and combination of 0.25 μM Trametinib and 1.25 μM Gefitinib. Stimulation of TrkA and TrkB-expressing SH-...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD028943 | Pride
Phosphoproteomics Neuroblastoma. 
ProteomicsA structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia
Abstract Mutations activating RAS/RAF/MEK/ERK signaling are associated with poor outcome in acute myeloid leukemia (AML), but therapeutic targeting of this pathway is challenging. Here, we employ a structure-based, dynamic RAS pathway model to successfully predict RAF inhibitor (RAFi) combinations ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-24 | PXD063606 | Pride
Drug combinations Ras-mutant acute myeloid leukemia. Structure-based modelling 
ProteomicsAnalysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells
Ras is a key switch controlling cell behavior. In the GTP-bound form, Ras interacts with numerous effectors in a mutually exclusive manner, where individual Ras-effectors are likely part of larger cellular (sub)complexes. The molecular details of these (sub)complexes and their alteration in specific...
ORGANISM(S): Homo sapiens (Human) 
2023-02-23 | PXD035399 | Pride
Kras Affinity purification (ap)-mass spectrometry (ms) Protein-protein interactions 
ProteomicsProteome of Caco-2 cells, transfected with KRAS-G12D and stimulated with different conditions.
Description: (Supplemental data for Project PXD035399) “Analysis of context-specific KRAS-effectors (sub)complexes in Caco-2 cells”. Proteome of Caco-2 cells, transfected with KRAS-G12D and stimulated with different conditions.
ORGANISM(S): Homo sapiens (Human) 
2023-02-23 | PXD039404 | Pride
Caco-2 cells Proteome Kras 
ProteomicsProteomic mapping of the interactome of KRAS mutants identifies new features of RAS signalling networks and the mechanism of action of Sotorasib.
RAS proteins are key regulators of cell signalling and are master regulators of different cell functions including cell proliferation, differentiation and cell death. Point mutations in the genes of this family are common, particularly in the KRAS. These mutations were thought to cause the constativ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-15 | PXD043536 | Pride
Apms Ras Signalling 
ProteomicsProteomic profile of BxPC3 cells after RAD51 inhibition by treatment with BRC4
RAD51 protein is an evolutionarily conserved recombinase that plays a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. RAD51 inactivation by small molecules has been proposed as a strategy to impair the BRCA2/RAD51 binding and, ultimately, the HR pathway, with ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD042696 | Pride
Proteomie Rad51 Bxpc3 cells Brc4. 
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