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Premetamorphic Xenopus laevis tadpole tail respond to thyroid hormone by resorption. The goal of this experiment is to identify the genes involved in the TH-induced resorption tadpole tail and compare it to TH-induced proliferation and differentiation program in tadpole limb and brain. Xenopus tadpo...
ORGANISM(S): Xenopus laevis 
Hydroxylated polychlorinated biphenyls are the metabolites produced from polychlorinated biphenyls (PCBs) by drug-metabolizing enzyme cytochrome P450 1A1. These compounds are bound to transthyretin, a major plasma thyroid hormone-binding protein in amphibian tadpoles. The compounds-transthyretin com...
ORGANISM(S): Xenopus laevis 
During neuronal wiring, extrinsic cues trigger the local translation of specific mRNAs in axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly this mechanism operates, nor whethe...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-12-02 | PXD015650 | Pride
Transcriptomic analysis of NeuroD2 CRISPant stage 47 Xenopus laevis tadpole brains
We compared transcripts from whole brains dissected from stage 47 Xenopus laevis tadpoles from F0 NeuroD2 CRISPants and Cas9 injected control sibings. NeuroD2 knockdown brains had increased expression of cell cycle associated genes and decreased expression of chromatin modifing genes. Libraries were...
ORGANISM(S): Xenopus laevis 
2025-09-30 | GSE307156 | GEO
Premetamorphic Xenopus laevis tadpoles brain ventricle cells respond to thyroid hormone by proliferation and subsequent differentiation. The goal of this experiment is to identify the genes involved in the TH-induced proliferation pathway in tadpole brain and compare it to TH-induced proliferation a...
ORGANISM(S): Xenopus laevis unidentified 
2005-10-04 | GSE3402 | GEO
A mixture of chemicals found in human amniotic fluid disrupts brain gene expression and behavior in Xenopus laevis
Thyroid hormone induced changes in Xenopus laevis tadpole brain
We hypothesized that embryonic exposure to a mixture of chemicals (containing phenols, phthalates, pesticides, heavy metals, and perfluorinated, polychlorinated, and polybrominated compounds) identified as commonly found in the human amniotic fluid (as calculated in Fini et al., ) could lead to alte...
ORGANISM(S): Xenopus laevis 
2023-01-27 | GSE223829 | GEO
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