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MetabolomicsMetabolomic Profiling of the Striatum in Shank3 Knockout ASD Rats: Effects of Early Swimming Regulation

OBJECTIVE: This study aimed to investigate the regulatory impact of early swimming intervention on striatal metabolism in Shank3 gene knockout ASD model rats.

METHODS: Shank3 gene knockout exon 11-21 male 8-day-old SD rats were used as experimental subject...

2024-09-27 | MTBLS8577 | MetaboLights
UnknownGenome assembly of M. spongiola and comparative genomics of the genus Morchella provide initial insights into taxonomy and adaptive evolution.
Not available
S-EPMC11129363 | biostudies-literature
UnknownPseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1.
Not available
S-EPMC12547503 | biostudies-literature
ProteomicsHuman cholangiocarcinoma LC-MS/MS
We studied the effect of Ser30 with or without O-GlcNAc modification on K18 protein and its co-immunoprecipitated proteins in cholangiocarcinoma cells.The lysates from HuCCT1 shK18 stable cell line transfected with FLAG-K18-WT or FLAG-K18-S30A were captured with anti-FLAG beads, and then subjected t...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048144 | Pride
Hucct1 cells Proteomics K18 
ProteomicsHuman cholangiocarcinoma LC-MS/MS
The glycosylation landscape of Human cholangiocarcinoma (CCA), and how it affects CCA diagnosis and prognosis, has recently emerged as an appealing research field.In this study, we used chemical glycoproteomic analysis Click-iG for systematic profiling of intact glycopeptides in CCA and HIBEpiC cell...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048188 | Pride
Glycoproteomics Click-ig Cholangiocarcinoma 
ProteomicsIdentification of the potential receptor of Musclin on C3H10T1/2 cell using BioID assay
To identify the potential receptor mediating the effect of Musclin on thermogenic adipocytes, we conducted a proximity-dependent biotin identification (BioID) assay to obtain the interactome of Musclin on the plasma membrane of beige adipocytes.
ORGANISM(S): Mus musculus (Mouse) 
2023-06-13 | PXD041019 | Pride
Lc-msms Musclin Receptor Bioid 
ProteomicsClinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are recognized as a promising strategy for cell-free therapy, however, their therapeutic role in pulmonary fibrosis remains unrevealed. Here, we report the safety and efficacy of MSC-EVs from human umbilical cord (hUCMSC-EVs) evaluate...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD063385 | Pride
Extracellular vesicles  pulmonary fibrosis  nebulization delivery  lung function recovery  preclinical and clinical trials 
ProteomicsSelective androgen receptor degrader (SARD) to overcome antiandrogen resistance in castration-resistant prostate cancer
Clinical resistance such as androgen receptor (AR) mutation, AR overexpression, and AR splice variants (ARVs) restrict the second-generation antiandrogens benefit in patients with castration-resistant prostate cancer (CRPC). Several strategies have been implemented to develop novel antiandrogens to ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD035721 | Pride
Human prostate cancer cell 4d-label free proteomic analysis Lncap 
ProteomicsNeuroligin 2 Governs Synaptic Morphology and Function Through RACK1-Cofilin Signaling in Drosophila
Neuroligins are transmembrane cell adhesion proteins well-known for their genetic links to autism spectrum disorders. Neuroligins can function by regulating the actin cytoskeleton, however the factors and mechanisms involved are still largely unknown. Here, using the Drosophila neuromuscular junctio...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-10-06 | PXD045754 | Pride
Lc-ms Drosophila Neuroligin2 
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
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