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MicroRNAs play critical roles in various biological and metabolic processes. The function of miRNAs has been widely studied in model plants such as Arabidopsis and rice. However, the number of identified miRNAs and related miRNA targets in peach (Prunus persica) is limited. To understand further the...
ORGANISM(S): Prunus persica 
Interstrand crosslinks (ICLs) are highly toxic DNA lesions, which are repaired via a complex process that requires the coordination of several DNA repair pathways. Defects in ICL repair result in Fanconi anemia (FA), which is diagnosed with bone marrow failure, development abnormalities and high inc...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD012521 | Pride
We examined the complexity of replication fork composition upon DNA damage by employing a PCNA-based proteomic screen to uncover known and new players involved in replication and replication stress response. We used camptothecin or ultraviolet radiation, that lead to fork-blocking lesions, to establ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-14 | PXD011727 | Pride
Host-virus protein-protein interaction is the key component of SARS-CoV-2 life cycle, which can be targeted for therapeutic intervention. Thus, we conducted a comprehensive interactome study between the virus and host cell using tandem affinity purification (TAP) and BioID2 labeling strategies. In a...
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD023209 | Pride
The adenosine monophosphate-activated protein kinase (AMPK) complex is a key enzyme in regulating cellular energy homeostasis. This complex is well studied and it is known to function in many cellular pathways. However, the interactome of AMPK complex has not yet been systematically established, alt...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD015466 | Pride
Enrichment strategy for searching missing protein, LMW Proteins, differential solubilization
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005381 | PeptideAtlas
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