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ProteomicsInterrogation of RNA-bound proteome with XRNAX illuminates molecular alterations in the mouse brain affected with dysmyelination
We applied RNA-protein interactome capture method called XRNAX to shed light on RNA-bound proteome in the brain affected with dysmyelination. We found that sets of canonical RBPs that are known to regulate alternative splicing and being engaged in the formation of cytoplasmic granules are perturbed ...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-08 | PXD052011 | Pride
Pcbp1 Rna processing Mbnl1 Rna-protein interactions Rna granules Dysmyelination Rna binding proteins 
ProteomicsThe Human RNA-Binding Proteome and Its Dynamics during Translational Arrest
The data presented here was produced using XRNAX - a novel extraction method for protein-crosslinked RNA from UV-crosslinked cells. We apply XRNAX for three proteomic downstream applications. First, we purify ribonucleotide-crosslinked peptides from XRNAX extracts and use their identification as dir...
ORGANISM(S): Homo sapiens (Human) 
2018-12-06 | PXD010520 | Pride
Uv-crosslinking Nucleotide-crosslinked peptides Xrnax Protein-crosslinked rna extraction Rna-binding proteins Arsenite stress Translational arrest Human rna-binding proteome Ribophagy 
Genomics
"XRNAX-CLIP-seq on MCF7 cells for LMNB1 and EXOSC2"
PRJEB26442 | ENA
Genomics
"RNA-Seq Comparing TRIZOL and XRNAX Extracted RNA"
PRJEB26441 | ENA
ProteomicsA translational regulator MHZ9 modulates ethylene signaling in rice
In this project, we identified a novel RNA-binding protein, MHZ9. And we analyzed the potential proteins interacted with MHZ9 through immunoprecipitation-mass spectrometry (IP-MS). The N-terminal domain of MHZ9 (MHZ9-N) contains a putative RNA splicing and modification domain PRP4. To identify RNA b...
ORGANISM(S): Oryza sativa (Rice) 
2023-07-20 | PXD041240 | Pride
Q exactive mass spectrometer (thermo scientific) Gyf-domain Oryza_sativa Rna-crosslinked peptide 
ProteomicsProfiling the RNA-Binding Proteome of KSHV-Infected Cells Uncovers a Viral Strategy for Hijacking Host Signaling via RNA-Dependent Interactions
Viruses encode RNA-binding proteins (RBPs) to manipulate host processes and promote infection. However, due to limited genomic space, many viral proteins are multifunctional and may engage RNA through non-canonical domains, making their identification difficult using traditional sequence-based appro...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD068587 | Pride
Xrnax Virf1 co-ip Kshv Lc-ms/ms 
UnknownInferring Protein Function in an Emerging Virus: Detection of the Nucleoprotein in Tilapia Lake Virus.
Not available
S-EPMC8941909 | biostudies-literature
ProteomicsTranslation-coupled resolution of RNA-protein crosslinks
The aim of the measurements was to investigate RNA damage and RNA-protein crosslinks (RPC) formation in the context of aldehyde-induced toxicity. For this, a photoactivatable-ribonucleoside-enhanced crosslinking (PAR-CL) strategy using 4-thiouridine (4-SU) and UVA-radiation was used. The submitted d...
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD038332 | Pride
Rna-protein crosslinks 
ProteomicsMHZ9 binding proteins identified by MHZ9-GFP IP-MS
Results from the analysis of MHZ9 interaction protein candidates by using immunoprecipitation-mass spectrometry (IP-MS).
ORGANISM(S): Oryza sativa (Rice) 
2023-07-20 | PXD041183 | Pride
Q exactive mass spectrometer (thermo scientific) Oryza_sativa 
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