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GenomicsNHLBI and NIDDK Sponsored GWAS in Benign Ethnic Neutropenia/Leukopenia (BEN) in African-Americans (age >45 yrs old) from the REGARDS

Benign ethnic neutropenia (BEN) is a clinical condition more commonly observed in African-Americans. It is characterized by a relative reduction in neutrophil count by about 1000 cells per microliter, leading to a decrease in total leukocyte count by similar decrement. Previous reports of this co...

phs000507.v1.p1 | EGA
ProteomicsMolecular basis of b-adrenergic regulation of cardiac calcium current
Increased cardiac contractility during fight-or-flight response is caused by b-adrenergic augmentation of CaV1.2 channels. It is assumed that this iconic regulation involves phosphorylation of CaV1.2 a1/b-subunits. In transgenic murine hearts expressing fully PKA phosphorylation-deficient mutant a1C...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD014499 | Pride
Streptavidin Apex Apex2 Alkaline reversed phase peptide fractionation H2o2 Denaturing purification Sps ms3 Cardiac calcium channel B-adrenergic regulation Isobaric labeling Isoproterenol Tmt Proximity labeling Biotin-phenol Quantitative mass spectrometry Cav1.2 Biotin-tyramide On-bead digest Peroxidase catalyzed 
ProteomicsMolecular basis of b-adrenergic regulation of cardiac calcium current
Increased cardiac contractility during fight-or-flight response is caused by b-adrenergic augmentation of CaV1.2 channels. It is assumed that this iconic regulation involves phosphorylation of CaV1.2 a1/b-subunits. In transgenic murine hearts expressing fully PKA phosphorylation-deficient mutant a1C...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD014501 | Pride
Isobaric labeling Isoproterenol Tmt Alkaline reversed phase peptide fractionation Non-transgenic Cardiomyocytes Quantitative mass spectrometry Sps ms3 B-adrenergic regulation 
ProteomicsMolecular basis of b-adrenergic regulation of cardiac calcium current
Increased cardiac contractility during fight-or-flight response is caused by b-adrenergic augmentation of CaV1.2 channels. It is assumed that this iconic regulation involves phosphorylation of CaV1.2 a1/b-subunits. In transgenic murine hearts expressing fully PKA phosphorylation-deficient mutant a1C...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD014500 | Pride
Streptavidin Apex Apex2 Alkaline reversed phase peptide fractionation H2o2 Denaturing purification Sps ms3 Cardiac calcium channel B-adrenergic regulation Isobaric labeling Isoproterenol Tmt Proximity labeling Biotin-phenol Quantitative mass spectrometry Cav1.2 Biotin-tyramide On-bead digest Peroxidase catalyzed 
TranscriptomicsTranscription profiling of human hepatoma Hep3B cells following irradiation to investigate the effects of DNA damage
To monitor the changes in transcription and alternative splicing upon UV irradiation, human hepatoma Hep3B cells were Hep3B cells were washed two times with PBS and then irradiated with 40J/m2 UV light; fresh medium was immediately added after the irradiation and the cells were incubated at 37 C and...
ORGANISM(S): Homo sapiens 
2009-07-10 | E-MEXP-2353 | biostudies-arrayexpress
UnknownCD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.
Not available
S-EPMC4974466 | biostudies-literature
UnknownProteomic analysis of primary duck hepatocytes infected with duck hepatitis B virus.
Not available
S-EPMC2904733 | biostudies-literature
MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
MetabolomicsPlasmid-encoded toxin defence mediates mutualistic microbial interactions

Gut environments harbour dense microbial ecosystems in which plasmids are widely distributed. Plasmids facilitate the exchange of genetic material among microorganisms while enabling the transfer of a diverse array of accessory functions. However, their precise impact on microbial community compo...

2023-08-10 | MTBLS7248 | MetaboLights
MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
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