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OtherDeep Proteomic Profiling of Vasopressin-Sensitive Collecting Duct Cells
Data from ProteomeXchange, PXD ID: PXD002434. File: 335.mzml. Published as part of Am J Physiol Cell Physiol. 2015 Aug 26:ajpcell.00214.2015 and Am J Physiol Cell Physiol. 2015 Aug 26:ajpcell.00213.2015
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320018959 | GPMDB
Resource Reanalysis 
ProteomicsMulti-omics Analyses Reveal Sex Differences in Mouse Renal Proximal Tubules
Sex-dependent differences in kidney function have been recognized. However, the molecular mechanisms underlying these differences remain largely unexplored. Advances in genomics and proteomic technologies now allow for an extensive characterization of sex differences. In this study, the authors appl...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD037098 | Pride
Kidney Multi-omics Sex difference 
ProteomicsSignaling in Renal Compensatory Hypertrophy Revealed by Multi-Omics_Outer Cortex
This mouse kidney outer cortex proteomics data set is part of multi-omic approach in a mouse unilateral nephrectomy model to identify signaling processes associated with compensatory hypertrophy of the renal proximal tubule.
ORGANISM(S): Mus musculus (Mouse) 
2023-06-05 | PXD039697 | Pride
Unilateral nephrectomy Multi-omics Hypertrophy Proteomics Kidney 
ProteomicsEarly Signaling Events in Renal Compensatory Hypertrophy Revealed by Multi-Omics
Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we used a multi-omic approach in a mouse unilateral nephrectomy model to identify signaling processes associated with...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-05 | PXD036395 | Pride
Transcriptome Pparα Proximal tubule Unilateral nephrectomy Proteome Hypertrophy 
ProteomicsPKA-Independent Vasopressin Signaling in Renal Collecting Duct
Vasopressin regulates renal water excretion by binding to the Gs-coupled vasopressin receptor (V2R) in collecting duct cells, resulting in cyclic AMP-dependent increases in epithelial water permeability through regulation of the aquaporin-2 (AQP2) water channel. Our prior studies showed that CRISPR...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD015719 | Pride
Mpkccd Phosphoproteomics Ampk Silac Prm-ms 
ProteomicsDeep Proteomic Profiling of Vasopressin-Sensitive Collecting Duct Cells
The mouse mpkCCD cell line is a continuous cultured epithelial cell line with characteristics of renal collecting duct principal cells. This line is widely used to study epithelial transport and its regulation. To provide a data resource useful for experimental design and interpretation in studies ...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-06 | PXD002434 | Pride
Sds-page Kidney cortical collection duct Mass spectrometry Aquaporin-2 Differential centrifugation Lc-ms/ms 
ProteomicsBayesian Analysis of Dynamic Phosphoproteomic Data Identifies Protein Kinases Mediating Responses to a Galphas-Coupled GPCR
A major goal in the discovery of signaling networks is to identify regulated phosphorylation sites and map them to the protein kinases responsible for their phosphorylation. The V2 vasopressin receptor is a Galphas-coupled GPCR that is responsible for regulation of renal water excretion through cont...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-06-17 | PXD031332 | Pride
Phospho proteomics Vasopression Protein kinases Baysian analysis Gpcr 
ProteomicsCRISPR-Cas9/phosphoproteomics identifies Myosin Light Chain Kinase dependent signaling in kidney epithelial cells
Prior studies have implicated myosin light chain kinase (MLCK) in the regulation of aqua-porin-2 (AQP2) in the renal collecting duct. To discover signaling targets of MLCK, we deleted the Mylk- gene to obtain MLCK-null mpkCCD cells and carried out comprehensive phosphopro-teomics using the SILAC met...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-04 | PXD014985 | Pride
Nuclear membrane Mass spectrometry Vasopressin Aqp2 Endosomal trafficking Sted microscopy 
ProteomicsPKA signaling network-quantitative proteomics and phosphoproteomics
Classically, connections within a complex network can be identified through systematically removing its components one at a time and observing the resulting functional changes throughout the network. We applied this concept to identify the signaling network downstream from protein kinase A (PKA) in...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-23 | PXD005938 | Pride
Mouse Kindey Pka Proteomics Phosphorylation 
ProteomicsRegulation of Cl- signaling and ion transport by IRBIT-mediated recruitment of multiple kinases and phosphatases
IRBIT is a multifunctional protein that controls the activity of IP3 receptors and the transporters NBCe1-B, CFTR and Slc26a6, by an unknown mechanism. IRBIT interacts with the NBCe1-B N terminus autoinhibitory domain (AID), exposing two cryptic Cl- sensing GXXXP sites to confer regulation of NBCe1-...
ORGANISM(S): Homo sapiens (Human) 
2020-03-04 | PXD010598 | Pride
Proteomics Irbit Ion channel Phosphorylation 
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