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ProteomicsProtein Identification and Post-translational Analysis of DMD and its associated Proteins in H19-proficient and -deficient Cells
Dystrophin proteomic regulation in Muscular Dystrophies (MD) remains unclear. We report that a long noncoding RNA (lncRNA) H19 associates with dystrophin. To investigate the biological roles of this interaction in vivo, we performed mass spectrometry analysis of dystrophin and its associated protein...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-19 | PXD020566 | Pride
Nifenazone Mouse Dystrophin Dmd Agr-h19 Lc-ms Bmd C2c12 H19 
Transcriptomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [GRO-seq]
Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatiz...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55903 | biostudies-arrayexpress
Genomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [Drug-seq]
Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatiz...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55901 | biostudies-arrayexpress
ProteomicsAnalysis of human AKT PH domain using limited proteolysis (LiP) followed by LC-MS/MS
We identified that a lncRNA named Long Intergenic Noncoding RNA for Kinase Activation (LINK-A, also LINC01139) directly and specifically interacts with AKT and PIP3. The LINK-A-AKT and -PIP3 interactions facilitate AKT recruitment and consequent activation. we also identified the single nucleotides ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-10 | PXD005636 | Pride
Human Pip3 Akt Ph domain Lip Lc-ms/ms 
UnknownThe OsOXO2, OsOXO3 and OsOXO4 Positively Regulate Panicle Blast Resistance in Rice.
Not available
S-EPMC8179873 | biostudies-literature
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq II]
While thousands of long non-coding RNAs (lncRNAs) are expressed in higher eukaryotes, the potential regulatory roles of lncRNAs in regulated gene transcription programs remain rather poorly understood. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 and PC...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47806 | biostudies-arrayexpress
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq I]
While thousands of long non-coding RNAs (lncRNAs) are expressed in higher eukaryotes, the potential regulatory roles of lncRNAs in regulated gene transcription programs remain rather poorly understood. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 and PC...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47805 | biostudies-arrayexpress
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [ChIRP-seq]
While thousands of long non-coding RNAs (lncRNAs) are expressed in higher eukaryotes, the potential regulatory roles of lncRNAs in regulated gene transcription programs remain rather poorly understood. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 and PC...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47804 | biostudies-arrayexpress
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47807 | biostudies-arrayexpress
ProteomicsDecoding protein glycosylation by an integrative mass spectrometry-based de novo sequencing strategy
Glycoprotein is one of the most complex biomacromolecule，accounting for over 50% of total human proteins and the majority of biopharmaceuticals, exerting profound influences on various essential biological processes. With multiple N-glycosylation sites and O- glycosylation sites on the protein backb...
ORGANISM(S): Homo Sapiens Bos Taurus 
PXD055221 |
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