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ProteomicsCharacterization of RAS and SLC3A2 signaling in multiple myeloma
Oncogenic mutations within the RAS pathway are common in multiple myeloma (MM), an incurable malignancy of plasma cells. However, the mechanisms of pathogenic RAS signaling in this disease remain enigmatic and difficult to inhibit therapeutically. We employed an unbiased proteogenomic approach to ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031662 | Pride
Phosphoproteomes Nras Kras Slc3a2 Bioid2 Multiple myeloma 
UnknownXeniaphyllane and Xeniolide Diterpenes from the Deep-Sea Soft Coral <i>Paragorgia arborea</i>.
Not available
S-EPMC11465450 | biostudies-literature
ProteomicsMspire-Simulator: LC-MS shotgun proteomic simulator for creating realistic gold standard data - HEK cell lysate
The most important step in any quantitative proteomic pipeline is feature detection (aka peak picking). However, generating quality hand-annotated data sets to validate the algorithms, especially for lower abundance peaks, is nearly impossible. An alternative for creating gold standard data is to si...
ORGANISM(S): Homo sapiens (Human) 
2020-01-24 | PXD000477 | Pride
Human Ms-simulator Hek-293t Fasp 
UnknownAnthoteibinenes F-Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i>.
Not available
S-EPMC11767152 | biostudies-literature
TranscriptomicsChoriodecidual Infection Downregulates Angiogenesis and Morphogenesis Pathways in Fetal Lungs from Macaca Nemestrina
Intrauterine exposure to amniotic fluid (AF) cytokines is thought to predispose to bronchopulmonary dysplasia (BPD). We evaluated the effects of GBS exposure on RNA expression in fetal lung tissue to determine early molecular pathways associated with fetal lung injury that may progress to BPD. Ten ...
ORGANISM(S): Macaca nemestrina 
2013-04-23 | E-GEOD-39029 | biostudies-arrayexpress
UnknownLandscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers.
Not available
S-EPMC4570169 | biostudies-literature
ProteomicsProteomic and phosphoproteomic profiling of SFTPCI73T expressing patient-specific pluripotent stem cell-derived alveolar epithelial type 2 cells and their gene-edited corrected counterparts.
We performed proteomic and phosphoproteomic profiling of cells derived from human induced pluripotent stem cells (iPSCs) using our previously described distal lung directed differentiation protocol to generate alveolar epithelial type 2 cells (iAEC2s). We used the SPC2 human iPSC line and specifical...
ORGANISM(S): Homo sapiens (Human) 
2021-10-07 | PXD022334 | Pride
Autophagy Proteomics Pluripotent stem cells Pulmonary fibrosis Alveolar epithelial type 2 cells 
TranscriptomicsLarge-scale downregulation of cytokeratins in amniotic epithelium after Group B Streptococcus choriodecidual infection in Macaca nemestrina: a pathway to PPROM
Early events leading to intrauterine infection remain poorly defined, but may hold the key to a therapeutic intervention for preterm delivery. To determine early molecular pathways associated with membrane weakening that may progress to preterm premature rupture of membranes (PPROM), we examined th...
ORGANISM(S): Macaca nemestrina 
2014-11-18 | E-GEOD-46290 | biostudies-arrayexpress
UnknownExamining the relationship between plasma pTau181 and cognitive decline, structural brain integrity, and biological ageing in midlife.
Not available
S-EPMC12036385 | biostudies-literature
UnknownA mindfulness-based, cognitive, social, digital relapse-prevention intervention for youth with depression in Australia: study protocol for a randomised controlled trial of Rebound.
Not available
S-EPMC11603739 | biostudies-literature
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