Sort   by:  
 Page size 
ProteomicsDIA-based quantitative proteomic analysis of adult sec31a-nju221 zebrafish liver
We found that adult zebrafish bearing a homozygous hypomorphic mutation in the sec31a gene (sec31anju221) exhibited overt glycogenic hepatopathy. As an efforts to investigate how hepatic metabolic maladaptation happened in sec31anju221 fish, livers were dissected from the adult zebrafish and DIA-MS ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-08-28 | PXD048925 | Pride
Dia Sec31a Liver Zebrafish 
ProteomicsPlasma Proteomic Profiling Identifies a Six-Protein Panel for Grading and Predicting Intervertebral Disc Degeneration
In order to identify and validate specific plasma proteins associated with varying grades of intervertebral disc degeneration. By establishing a panel of potential biomarkers, this research seeks to enhance diagnostic accuracy and provide insights into the biological processes underlying IDD.A case-...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PAD000013 | Pride
Human Intervertebral disc degeneration Plasma Somascan 
ProteomicsDIA-based quantitative proteomic analysis of mitochondria of podocyte with Fructose treatment
We isolated mitochondria from fructose-incubated podocytes and performed data-independent acquisition (DIA)-based quantitative proteomics to analyze the global expression level of mitochondrial proteins.
ORGANISM(S): Homo sapiens (Human) 
2026-06-05 | PXD047317 | Pride
Podocyte Mitochondria Fructose 
ProteomicsCompound-centric chemical proteomics to screen fructose binding proteins
To identify protein targets of fructose, we performed a compound-centric chemical proteomics (CCCP) experiment on podocytes with P-fructose. Briefly, podocytes were incubated with P-fructose, and the cellular proteins that directly bind to fructose were covalently crosslinked to P-fructose by UV irr...
ORGANISM(S): Homo sapiens (Human) 
2026-06-05 | PXD047310 | Pride
Chemoproteomics Small molecule-protein interaction Fructose 
ProteomicsFAM134B oligomerization drives ER membrane scission for ER-phagy
ER degradation by selective autophagy (ER-phagy) is crucial for ER homeostasis. However, it remains unclear how ER scission is regulated for subsequent autophagosomal sequestration and lysosomal degradation. Here, we show that oligomer formation of FAM134B (also referred to as reticulophagy regulato...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016661 | Pride
Er-phagy  fam134b oligomerization  membrane fragmentation  er stress  camk2b 
ProteomicsHigh resolution mass spectrometry analysis of P-fructose-labeled Tom22 peptides
After identifying Tom22 as a direct target of fructose, we sought to map the potential sites that fructose binds to Tom22. We analyzed trypsin-digested peptides of P-fructose-labeled recombinant Tom22 by high-resolution mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2026-06-05 | PXD047275 | Pride
Small molecule-protein interaction Tom22 Fructose 
Sort   by:  
 Page size