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ProteomicsIntracellular proteins adsorbed on AuNPs during transcytosis and exocytosis
we set protein corona as the research object in this study, and focused on exploring the biological effects of intracellular protein corona (IPC) that formed on particle surface after transcytosis of nanomedicines. Considering the multi-functionalization characteristic, gold nanoparticles (AuNPs) we...
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD015651 | Pride
Transcytosis Exocytosis Protein corona Caco-2 Aunps 
MetabolomicsComprehensive transcriptome and metabolome analysis revealed the primary molecular regulatory pathways of skin development in Yulin black duck during embryonic stage
Skin color is one of the key characteristics the duck possesses which is used to determine the market value because it affects the consumer's purchasing decisions. People tend to prefer ducks with black skin because they are more suitable for making soup. This study was conducted to identify the sig...
2026-08-24 | MTBLS14916 | MetaboLights
Proteomicsproteomic analysis reveals the toxin diversity of the spider Macrothele bannaensis
pider toxins are an important and abundant source of bioactive compounds and represent molecular candidates for the development of novel compounds for use in medicine and agriculture. Despite the vast diversity of spider species, only a small fraction of them have been studied in detail regarding ve...
ORGANISM(S): Macrothele 
2025-07-09 | PXD065984 |
Proteomicspp6 is recruited in TNFalpha induced complex I
We identify pp6 is recruited in complex I induced by TNFalpha.
ORGANISM(S): Mus Musculus 
2021-12-14 | PXD030377 |
MetabolomicsGNPS - Serum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | GNPS
ProteomicsProteomic analysis of Rhitymna verruca
Rhitymna verruca is a large nocturnal wandering spider and an important natural predator of agricultural and forestry pests, with its venom playing a key role in prey capture. However, systematic studies on the composition of its venom remain scarce. In this study, we performed an integrated analysi...
ORGANISM(S): Unclassified Sparassidae 
2025-10-29 | PXD070066 |
ProteomicsThe proteomic navigator of human aging
Proteins are the cornerstone of human life, yet the proteomic landscape of aging across human tissues remains largely unexplored. Here, we present a comprehensive proteomic analysis of 520 samples from 15 human tissues, spanning a 50-year lifespan. Our study compiles a proteomic encyclopedia of mult...
ORGANISM(S): Homo Sapiens 
2024-12-06 | PXD058638 |
ProteomicsEffect of synchronicity of amino acid supply on the synthesis of protein in C2C12 myotubes cultured in vitro
This data further revealed the effect and mechanism of non-synchronous amino acid supply on myoglobin synthesis, and provided theoretical reference for animal precise nutrition.
ORGANISM(S): Mus Musculus 
2024-04-25 | PXD051755 |
ProteomicsPrelamin A interacts with RIPK1 in ZMPSTE24-deficient cells
To understand the gain-of-toxicity of unprocessed prelamin A, we sought to identify the specific binding proteins of prelamin A that do not interact with mature lamin A. Because prelamin A is specifically localized to the nuclear envelope, we used ascorbate peroxidase 2 (APEX2)-based proximity label...
ORGANISM(S): Homo Sapiens 
2024-01-31 | PXD049033 |
ProteomicsSENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
SENP1 deSUMOylates RIPK1 in TNF-R1 signaling complex (TNF-RSC), keeping RIPK1 in check. Loss of SENP1 leads to SUMOylation of RIPK1, which re-orchestrates TNF-RSC and modulates the ubiquitination patterns and activity of RIPK1.
ORGANISM(S): Mus Musculus 
2022-10-24 | PXD037648 |
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