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MetabolomicsTranscriptomic and metabolomic data of goat ovarian and uterine tissues during sexual maturation (Ovarian data)

The ovaries and uterus are crucial reproductive organs in mammals, and their coordinated development ensures the normal development of sexual maturity and reproductive capacity. This study aimed to comprehensively capture the different physiological stages of the goat's sexual maturation by selec...

2024-05-30 | MTBLS9794 | MetaboLights
MetabolomicsTranscriptomic and metabolomic data of goat ovarian and uterine tissues during sexual maturation (Uterine data)

The ovaries and uterus are crucial reproductive organs in mammals, and their coordinated development ensures the normal development of sexual maturity and reproductive capacity. This study aimed to comprehensively capture the different physiological stages of the goat's sexual maturation by selec...

2024-05-30 | MTBLS9795 | MetaboLights
ProteomicsStress Granule-associated ZmCTU2 Confers Thermotolerance in Maize via Coordinated Regulation of Proteostasis and ROS Homeostasis
we performed comparative proteomic analysis of wild-type B104 and ZmCTU2-overexpressing lines. Seedlings at three-leaf-stage were grown under normal temperature condition (NC; 25°C for 12 days) and subsequently subjected to heat stress (HS; 43°C for 8 hours following NC growth). Using tandem mass ta...
ORGANISM(S): Zea Mays 
2025-12-17 | PXD072171 |
ProteomicsSystematic Identification of SHP2 Phosphatase Substrates
Phosphatases play essential roles in normal cell physiology and diseases like cancer. The challenges of studying phosphatases have limited our understanding of their substrates, molecular mechanisms, and unique functions within highly complicate networks. Here we introduce a novel strategy using sub...
ORGANISM(S): Homo sapiens (Human) 
2022-09-20 | PXD028404 | Pride
Phosphoproteomics Tyrosine phosphatase substrates Lc-ms Shp2 
MetabolomicsComparative metabolomics reveals serum metabolites changes in goats during different developmental stages

Goats can provide meat, milk and skins for humans and are livestock with high economic benefits. However, despite their economic significance, the comprehensive analysis of goats' serum metabolic profile and its intricate alterations throughout their developmental journey remains conspicuously ab...

2024-06-04 | MTBLS8944 | MetaboLights
MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
ProteomicsThe effects of Cas5 on the protein biosynthesis of Candida albicans
Cas5, a transcriptional regulator of Candida albicans, has profound effects on the biosynthesis of cell wall proteins through regulating Candida albicans cell wall remodeling
ORGANISM(S): Candida Albicans 
PXD052043 |
TranscriptomicsComparative transcriptome analysis of Brassica napus L. male sterility induced by the Chemical Hybridization Agent Monosulfuron Ester Sodium
Chemical hybridization agent (CHA)-induced male sterility is becoming one of the most useful tools for the crop heterosis in seed production. We had previously discovered monosulfuron ester sodium (Mes), an acetolactate synthase (ALS) inhibitor of the herbicide sulfonylurea family, could induce rape...
ORGANISM(S): Brassica napus 
2015-12-05 | E-GEOD-53468 | biostudies-arrayexpress
ProteomicsThe BPAN disease protein WDR45 forms condensates with Caprin-1 to regulate stress granule disassembly
Beta-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder primarily caused by mutations in the WD repeat domain 45 (WDR45) gene. While WDR45 has traditionally been linked to autophagy, our study uncovers a previously unrecognized role for WDR45 as a cri...
ORGANISM(S): Homo Sapiens 
PXD062911 |
TranscriptomicsMicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation.
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here we report that miR-1, a microRNA specifically induced dur...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-57596 | biostudies-arrayexpress
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