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ProteomicsProteome validation for novel full-length genes in the giant panda
we applied RNA-seq to detect novel expressed transcripts in 12 tissues of giant pandas, using a transcriptome reconstruction strategy combining reference-based and de novo methods. Then we used mass spectrometry method to identify proteomes of five selected tissues, aiming at validating these novel...
ORGANISM(S): Ailuropoda melanoleuca (Giant panda) 
2015-12-23 | PXD002917 | Pride
Testis Pituitary Brain Giant panda Tongue Lc-ltq Ovary 
UnknownStructural basis of the activation of c-MET receptor.
The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal cell development and motility. Aberrant activation of c-MET can lead to both tumors growth and metastatic progression of cancer cells. C-MET can be activated by either hepatocyte growth factor (HGF), or its n...
S-EPMC8249616 | biostudies-literature
UnknownIdentifying depression with mixed features: the potential value of eye-tracking features.

Objectives

To investigate the utility of eye-tracking features as a neurobiological marker for identifying depression with mixed features (DMF), a psychiatric disorder characterized by the presence of depressive symptoms alongside subsyndromal manic features, thereby complicating both diagno...
S-EPMC11961420 | biostudies-literature
UnknownLamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells.
ATP binding cassette (ABC) transporters, such as P-gp, BCRP and MRP1, can increase efflux of clinical chemotherapeutic agents and lead to multi-drug resistance (MDR) in cancer cells. While the discovery and development of clinically useful inhibitors has proved elusive to date, this molecular target...
S-EPMC4113800 | biostudies-literature
UnknownAblation of interferon regulatory factor 4 in T cells induces "memory" of transplant tolerance that is irreversible by immune checkpoint blockade.
Achieving transplant tolerance remains the ultimate goal in the field of organ transplantation. We demonstrated previously that ablation of the transcription factor interferon regulatory factor 4 (IRF4) in T cells induced heart transplant acceptance by driving allogeneic CD4+ T cell dysfu...
S-EPMC6440205 | biostudies-literature
UnknownPlasma ddPCR for the detection of MET amplification in advanced NSCLC patients: a comparative real-world study.

Background

Mesenchymal-epithelial transition (MET) amplification is a crucial oncogenic driver and a resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) of non-small-cell lung cancer (NSCLC). Fluorescence in situ hybridization (FISH) is th...
S-EPMC10851729 | biostudies-literature
UnknownAerobic glycolysis enables the effector differentiation potential of stem-like CD4<sup>+</sup> T cells to combat cancer.
Not available
S-EPMC11061150 | biostudies-literature
UnknownThe transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo.
The exact relationships between group 2 innate lymphoid cells (ILC2s) and Th2 cells in type 2 pathology, as well as the mechanisms that restrain the responses of these cells, remain poorly defined. Here we examined the roles of ILC2s and Th2 cells in type 2 lung pathology in vivo using germline and ...
S-EPMC7852540 | biostudies-literature
UnknownT cell exhaustion is associated with antigen abundance and promotes transplant acceptance.
Exhaustion of T cells limits their ability to clear chronic infections or eradicate tumors. Here, in the context of transplant, we investigated whether T cell exhaustion occurs and has a role in determining transplant outcome. A peptide/MHC tetramer-based approach was used to track exhausted CD8
S-EPMC8000649 | biostudies-literature
UnknownEpigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics.
Foxp3+ regulatory T cells (Tregs) are potent immunoregulatory cells, prompting strong interests in manipulating them for therapeutic purposes. However, significant challenges remain, including their heterogeneity and functional instability. Here we focused on the inducible Tregs (iTregs) and studied...
S-EPMC7483360 | biostudies-literature
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