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MetabolomicsIntestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim t...
2023-01-09 | MTBLS4040 | MetaboLights
ProteomicsMitten crab hepatopancreas LC-MSMS
As representatives of n-6 and n-3 fatty acids, many studies have analyzed the use of soybean oil and linseed oil rich in linoleic acid (18:2n-6, LA) and α-linolenic acid (18:3n-3, LNA) as better substitutes for fish oil. In aquatic animals, different dietary ratios of LA and LNA could have significa...
ORGANISM(S): Eriocheir sinensis (Chinese mitten crab) 
2019-08-14 | PXD009864 | Pride
Lc-msms Linoleic acid Α-linolenic acid Eriocheir sinensis Hepatopancreas 
ProteomicsA multiplex fragment ion-based method for accurate proteome quantification
We developed a multiplex pseudo-isobaric dimethyl labeling (m-pIDL) method for proteome quantification to extend the capacity of the fragment ion-based method to 6-plex by one-step dimethyl labeling with several millidalton and dalton mass differences between precursor ions and enlarging the isolati...
ORGANISM(S): Homo Sapiens Escherichia Coli 
2019-01-22 | PXD012457 |
TranscriptomicsGene expression patterns of sulfur starvation in Synechocystis sp. PCC 6803
The unicellular cyanobacterium Synechocystis sp. PCC 6803 is a model system for studying biochemistry, genetics and molecular biology of photobiological processes. Despite its importance in basic and applied research, the genome-wide picture of transcriptional regulation in this bacterium is limited...
ORGANISM(S): Synechocystis sp. PCC 6803 
2008-07-24 | E-GEOD-11970 | biostudies-arrayexpress
TranscriptomicsComparison of transcriptome profile between wild-type and dao mutant plants
We identified and characterized that the rice Dioxygenase for Auxin Oxidation (dao) mutant displays pleiotropic phenotypes, including indehiscent anthers, sterile pollens, and increased free IAA levels in anthers.We conclude that DAO-mediated auxin catabolism is essential for auxin homeostasis and l...
ORGANISM(S): Oryza sativa Japonica Group 
2012-09-25 | E-GEOD-41097 | biostudies-arrayexpress
MetabolomicsComprehensive transcriptome and metabolome analysis revealed the primary molecular regulatory pathways of skin development in Yulin black duck during embryonic stage
Skin color is one of the key characteristics the duck possesses which is used to determine the market value because it affects the consumer's purchasing decisions. People tend to prefer ducks with black skin because they are more suitable for making soup. This study was conducted to identify the sig...
2026-08-24 | MTBLS14916 | MetaboLights
ProteomicsPDZ domain-containing adaptor protein GIPC1 interacts with the SR-B1 and modulates its expression and lipid transport function
PDZ family protein GIPC1 physically interacts with SR-B1 and regulates SR-B1 expression by promoting SR-B1 protein stability.
ORGANISM(S): Mus Musculus 
2021-03-09 | PXD024595 |
ProteomicsFunctional Human Salivary Gland Organoids for Tissue Regeneration in Chemically Defined Culture Systems
Salivary gland dysfunction significantly impairs patients' quality of life, yet effective regenerative therapies remain clinically unavailable. In this study, we established a fully chemically defined, xeno-free three-dimensional culture system to generate functional human salivary gland organoids. ...
ORGANISM(S): Mus Musculus 
2025-07-22 | PXD066438 |
TranscriptomicsBone marrow gene expression of pediatric acute lymphoblastic leukemia (ALL)
Pediatric acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Subtype classification can be also achieved through gene expression profiling. However, how to apply such classifiers to a single patient and correctly diagnose the di...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-17703 | biostudies-arrayexpress
MetabolomicsSensing Ceramides by CYSLTR2 and P2RY6 to Aggravate Atherosclerosis

Recent evidence shows elevated circulating long-chain ceramide levels predicts atherosclerotic cardiovascular disease (ASCVD) independently of cholesterol. Although targeting ceramides signaling may provide therapeutic benefits beyond the treatment of hypercholesterolemia, the underlying mechanis...

2025-04-15 | MTBLS11925 | MetaboLights
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