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TranscriptomicsFoxM1 is essential for quiescence and maintenance of hematopoietic stem cell
FoxM1, a mammalian Forkhead Box M1 protein, is known as a typical proliferation-associated transcription factor that regulates of G1/S and G2/M transition in the proliferating cells. However, the in vivo function of FoxM1 in adult stem cells remains unknown. Here, we found that FoxM1 is highly expr...
ORGANISM(S): Mus musculus 
2015-06-15 | E-GEOD-62360 | biostudies-arrayexpress
UnknownNeoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Not available
S-EPMC6145832 | biostudies-literature
ProteomicsEZH2 pre-mRNA pull-down screening for proteins that regulate EZH2 alternative splicing
Post-transcriptional regulation mediated by RNA-binding proteins is essential for B cell development and differentiation. EZH2 is a key regulatory protein involved in B cell development and the germinal center response, and its expression is subject to alternative splicing regulation. Skipping of ex...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-30 | PXD077818 | Pride
Pull down Ezh2 
ProteomicsUrsodeoxycholic acid promoted TGF-β degradation
MS analysis of proteins interacting with PKA and TGF-β1 in HEK293T cells. MS analysis of immunoprecipitated TGF-β1 in HEK293T cells with TGF-β1 overexpression.
ORGANISM(S): Mus musculus (Mouse) 
2022-06-28 | PXD031801 | Pride
Tgf-β1 Pka Phosphorylation modification 
UnknownDevelopment of a multiple convolutional neural network-facilitated diagnostic screening program for immunofluorescence images of IgA nephropathy and idiopathic membranous nephropathy.
Not available
S-EPMC10689194 | biostudies-literature
ProteomicsMFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
To identify which E3 ligases ubiquitinate PD-L1, we overexpressed PD-L1-Flag in HEK293 cells and used anti-Flag magnetic beads to pull down PD-L1 from cell lysates. The interacting proteins were then analyzed by mass spectrometry, revealing that three E3 ligases interact with PD-L1.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057691 | Pride
Anti-pd-1-therapy resistance Ube4a Extracellular vesicles Mfge8 Pd-l1 
ProteomicsMFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
To elucidate which secreted factors in tumor tissues (TTs) are responsible for the upregulation of UBE4A as the tumor progresses, we inoculated tumors in mice and analyzed the 2- and 4-week TT fluid by mass spectrometry (MS). By combining molecular weight cut off(MWCO) and the identification of secr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058079 | Pride
Anti-pd-1-therapy resistance Ube4a Extracellular vesicles Mfge8 Pd-l1 
ProteomicsMass spectrometry analysis of proteins interacting with Fbxw7 in T cells
To elucidate how gut microbiota (GM) downregulated Fbxw7, we treated CD4+ T cells with GM-lysates and pulled down Fbxw7 in the cell lysates. Then, the precipitated proteins were analyzed by mass spectrometry, and eight E3 ligases were revealed to interact with Fbxw7.
ORGANISM(S): Mus musculus (Mouse) 
2025-04-16 | PXD057140 | Pride
Fbxw7  trim21  th17 cells  gut microbiota 
ProteomicsType I interferon/STAT1 signaling negative feedback regulates UBE2M-mediated antiviral innate immunity
To identify potential proteins involved in RIG-I regulation, we pulled down RIG-I from HEK293T or NIH-3T3 cells overexpressing RIG-I, and the RIG-I-bound proteins were then analyzed by mass spectrometry (MS).
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-01-30 | PXD039071 | Pride
Hek293t nih-3t3 lc-msms rig-i ube2m 
UnknownElectrocatalytic Self-Coupling of N-Heterocyclic Amides for Energy-Efficient Bipolar Hydrogen Production.
Not available
S-EPMC12765757 | biostudies-literature
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