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ProteomicsProteomic profiles of Rat Pancreatic Islets
In this study, we achieved integrated transcriptomic and proteomic profiles of GK islets in a time-course fashion at different stages of T2D. Subsequent bioinformatics analysis revealed the chronological order of T2D-related molecular events during the deterioration of pancreatic islets. Our large q...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-06-02 | PXD004709 | Pride
Rat islets proteome 
ProteomicsIdentification of novel 53BP1 associated proteins
We used homologous recombination based CRISPR Knock-in strategy to insert a SFB tag at C terminal of 53BP1 in 293T cells. We performed tandem affinity purification of endogenous 53BP1 in both soluble and chromatin fraction to uncover known and new 53BP1 binding proteins which might play roles in DNA...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020090 | Pride
53bp1 
ProteomicsHuman WW-domain containing proteins TAP-LC-MSMS
To systematically investigate the regulations and functions of human WW-domain containing proteins, we conducted a proteomic analysis of 26 full-length WW-domain containing proteins and 17 WW-domains only, and identified their associated protein complexes in human HEK293T cells using tandem affinity...
ORGANISM(S): Homo sapiens (Human) 
2019-12-02 | PXD004649 | Pride
Human Lc-msms Ww-domain containing proteins Tap 
ProteomicsMutant p53 interactome study with IP-MS
Inactivating TP53 mutations lead to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promote tumor development and progression. The GOF activities of TP53 mutations are well documented, but the mechanisms involved remain p...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD047094 | Pride
Ms Ip Mutant p53 P53 
ProteomicsHigh-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning
We develop a parallel flow projection and transfer learning-based spatial proteomics framework that combines microfluidics and a deep neutral network.
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus 
2025-01-15 | PXD045687 |
ProteomicsGlobal Proteomic Analysis Reveals the Roles of MicX in Biofilm Formation and Quorum Sensing in Vibrio alginolyticus
Vibrio alginolyticus is a foodborne pathogen commonly found in seafood and freshwa-ter products, causing human illness through the consumption of tainted seafood. Small non-coding RNAs (sRNAs) take effect on the stability and translation of their target mRNAs by base pairing, thereby quickly alterin...
ORGANISM(S): Vibrio Alginolyticus Nbrc 15630 = Atcc 17749 
2026-02-05 | PXD073542 |
ProteomicsRice OsFIE2-FLAG IP-MS analysis
To analyze the interaction proteins of Polycomb complex PRC2 in rice, we used the FIE2-FLAG transgenic material to perform IP-MS analysis.
ORGANISM(S): Oryza Sativa 
2022-04-22 | PXD033370 |
ProteomicsOTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
To explore the underlying mechanism by which OTUD6A induces PCa progression, we identified its binding proteins with an immunoprecipitation (IP)-mass spectrometry (MS) approach in two CRPC cell lines.
ORGANISM(S): Homo Sapiens 
2022-01-28 | PXD031307 |
ProteomicsGlioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4
Almost all high-grade gliomas, particularly glioblastoma (GBM), are highly migratory and aggressive. Migrasomes are organelles produced by highly migratory cells capable of mediating intercellular communication. Thus, GBM cells may produce migrasomes during migration. However, it remains unclear whe...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057558 |
MetabolomicsAberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

OBJECTIVE: Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and rena...

2020-10-20 | MTBLS700 | MetaboLights
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