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ProteomicsLandscape of the Regulatory Elements for Lysine 2-Hydroxyisobutyrylation Pathway
This project reported a comprehensive global lysine 2-hydroxyisobutyrylome that provided a dataset of 6548 reliable lysine 2-hydroxyisobutyrylation (Khib) sites on 1725 proteins in HeLa cells. This dataset represents the first Khib proteome in mammalian cell to date, and illustrates a broad landscap...
ORGANISM(S): Homo sapiens (Human) 
2017-12-06 | PXD005414 | Pride
Hela Ptm Lysine 2-hydroxyisobutyrylation 
ProteomicsKcr proteome in response to p300 KO
We used quantitative proteomics to characterize the p300-regulated lysine crotonylome in wild type (WT) and p300 knockout (KO) cells.
ORGANISM(S): Homo sapiens (Human) 
2018-06-26 | PXD006407 | Pride
Crotonylation P300 Quantitative proteomics 
ProteomicsKbhb proteome in 293 cells
We performed an global Kbhb proteome screening and identified ~3000 Kbhb substrate.
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012328 | Pride
Kbhb Ptms Proteome 
ProteomicsMouse Liver Lysine β-hydroxybutyrylome
Characterization of the lysine β-hydroxybutyrylome, proteome-wide, will start to define its cellular targets and enable investigation of its impact under ketogenesis. Here, we show the induction of global protein Kbhb in the liver. We identified 891 sites of Kbhb within 267 proteins belonging to mac...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD016654 | Pride
Mouse Liver Lysine β-hydroxybutyrylation 
GenomicsIdentification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslationa...
ORGANISM(S): Mus musculus 
2011-10-06 | E-GEOD-32663 | biostudies-arrayexpress
TranscriptomicsA comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation
Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransfera...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-11 | E-GEOD-9771 | biostudies-arrayexpress
ProteomicsHistone Kla is regulated by cellular glycolysis
We have identified a new histone modification, which is derived from glycolysis end product, lactate. By SILAC-MS/MS based quantification, and U-13C6 glucose labeling experiments, we demonstrate that histone Kla is regulated by cellular glycolysis pathway
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014870 | Pride
Human mcf-7 cells silac 
ProteomicsKetone Bodies-mediated Cysteine Modifications Discovered by Chemical Proteomics
All the studies of ketone body-dependent post-translational modifications (PTMs), notably those mediated by ketone bodies, β-hydroxybutyrate (Bhb) and acetoacetate (Acac), have focused on lysine acylations. However, given the chemically diverse and reactive nature of metabolites generated, it remain...
ORGANISM(S): Homo Sapiens 
PXD066371 |
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