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ProteomicsHuh-7 Over-expression FNDC4 LC-MS
To clarify the molecular mechanism by which FNDC4 promotes HCC invasion, mass spectrometry (MS) analysis was performed on the lysates of Huh-7-overexpressing FNDC4 and normal Huh-7 cells.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025623 | Pride
Liver cancer Fndc4 Lc-ms 
ProteomicsIdentification of proteins that interact YAP TAD or MED15 through BioID
Transcriptional coactivators of YAP/TAZ play key roles tumor initiation, progression, and cancer immunotherapy resistance through transcriptional outputs.We performed YAP and MED15 BioID-Mass spec to determine the interaction network and their roles in the transcriptional regulation mechanism.
ORGANISM(S): Homo sapiens (Human) 
2025-04-02 | PXD053795 | Pride
Human 
ProteomicsA mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy
Transcriptional coactivators of YAP/TAZ play key roles in cancers through transcriptional outputs. However, the mechanisms of their transactivation remain unclear, and effective and safe targeting solutions are lacking. Here, we discovered that YAP/ TAZ possess a hydrophobic transactivation domain (...
ORGANISM(S): Homo sapiens (Human) 
2025-04-02 | PXD060955 | Pride
Cancer therapy Yap/taz Transactivation 
ProteomicsProteomic Analysis of Ginkgolic Acid Targets in HCCLM3 Cells via DARTS-LC-MS/MS
This study aims to identify the potential protein targets of Ginkgolic Acid in human hepatocellular carcinoma HCCLM3 cells using the Drug Affinity Responsive Target Stability (DARTS) assay combined with LC-MS/MS proteomics. Whole cell lysates from Ginkgolic Acid-treated and vehicle control (DMSO) HC...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD073111 | Pride
UnknownThe mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy.
Not available
S-EPMC12022045 | biostudies-literature
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