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ProteomicsIntegrated proteomic and transcriptomic analyses reveal the roles of Brucella BI-1 in cell division and membrane homeostasis of Brucella suis S2
To explore the role of Brucella BI-1 in Brucella suis S2, we constructed the Brucella BI-1 deletion mutant strain and its complementary strain. We then determined the effect of Brucella BI-1 deletion on the physiological characteristics of Brucella suis S2 and revealed them via integrated transcript...
ORGANISM(S): Brucella Suis Bv. 1 Str. S2 
2020-11-13 | PXD022537 |
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
ProteomicsLabel-free proteomics of endometrial epithelial cell for identification of presumptive biomarkers of endometritis
A total of 1180 proteins were identified in the control group and endometritis model group, of which 313 differential proteins were accurately quantified. The proteomic results were verified by WB, TEC and IF techniques, and the same conclusion was obtained.
ORGANISM(S): Capra Hircus 
2022-05-18 | PXD033950 |
ProteomicsUbiquitylation-omics analysis on WWP2 overexpressed mouse tubular epithelial cells (MPTCs)
WWP2 is a E3 ubiquitin ligase which may be implicated in multiple cellular event. WWP2 expressed in the kidneys and its pathological role remain to be elucidated. We performed this ubiquitylation omics analysis on renal tubular epithelial cells which overexpressd WWP2 to study WWP2's potential ubiqu...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD048540 | Pride
Renal tubular epithelial cells Ubiquitylation-omics 
ProteomicsQuantitative proteinomics on WWP2 overexpressed human tubular epithelial cells HK-2
WWP2 is a E3 ligase which regulates multiple cellular events, such as stress response, differentiation. WWP2 played physiological role in the distal tubules of the kidneys. Whether WWP2 regulated pathophysiological rol in the proximal tubules is unclear. In the present study, we stably overexpressed...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD048622 | Pride
Human tubular epithelial cells Wwp2 Proteinomics 
TranscriptomicsMiR-34b regulates multiciliogenesis during organ formation in zebrafish
Multiciliated cells possess multiple motile cilia on the cell surface and are widely distributed throughout the vertebrate body to perform important physiological functions by regulating fluid movement in the intercellular space. However the molecular mechanisms underlying multiciliogenesis are not ...
ORGANISM(S): Danio rerio 
2013-06-14 | E-MEXP-3893 | biostudies-arrayexpress
MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
Proteomicsmass spectrometry analysis of in vitro kinase assay for DNA-PKcs and TAF7
To examine whether TAF7 could be phosphorylated by DNA-PKcs directly. An in vitro kinase assays were performed. Firstly, human DNA-PKcs was purified from TGF1 treated HK2 cells by immunoprecipitation with a DNA-PKcs antibody (abcam) and IgG was used as a negative control. The purified proteins and ...
ORGANISM(S): Homo Sapiens 
2022-09-22 | PXD036930 |
ProteomicsProteomic study on lavage fluid of Dairy cows 30 days after delivery
Lipopolysaccharide (LPS) is a component of the outer membrane of gram-negative bacteria that is involved in pathogenic processes leading to postpartum metritis and endometritis in dairy cow. It also causes inflammation of the endometrium. This study aimed to investigate the effects of LPS on cow end...
ORGANISM(S): Bos Taurus 
2022-08-23 | PXD036248 |
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