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ProteomicsLabel-Free Absolute Protein Quantification with Data-Independent Acquisition
Label-free absolute quantitative proteomics is commonly used for absolute quantification of the proteome or specific proteins of interest in various biological samples. Current label-free absolute protein quantification (APQ) methods determine MS1 intensities, MS2 spectral counts or intensities to a...
ORGANISM(S): Homo sapiens (Human) 
2019-03-20 | PXD010912 | Pride
Human Dia S9 Absolute protein quantification Microsome Liver Dda 
ProteomicsGenome-wide pQTL analysis of protein expression regulatory networks in the human liver
Background: Previous expression quantitative trait loci (eQTL) studies have identified thousands of genetic variants to be associated with gene expression at the mRNA level in the human liver. However, protein expression often correlates poorly with mRNA levels. Thus, protein quantitative trait loci...
ORGANISM(S): Homo sapiens (Human) 
2020-07-21 | PXD019169 | Pride
Liver Hls9 Dia 
ProteomicsA Novel QconCAT-Based Proteomics Method for Determining Allele-Specific Protein Expression (ASPE)
In the present study, we developed a novel targeted proteomics approach for quantification of allele-specific protein expression (ASPE) based on scheduled high resolution multiple reaction monitoring (sMRM-HR) with a heavy stable isotope-labeled quantitative concatamer (QconCAT) internal protein sta...
ORGANISM(S): Homo sapiens (Human) 
2018-08-28 | PXD008788 | Pride
Human Allele-specific protein expression Liver 
ProteomicsComparison of Protein Expressions of Drug-Metabolizing Enzymes between Human Liver and the Hepatic Cell Lines HepG2, Hep3B and Huh7 using SWATH and MRM-HR Proteomics
Human hepatic cell lines have been widely used as an in vitro model for the study of drug metabolism and liver toxicity. However, the validity of this model is still a subject of debate because the expressions of various proteins including drug-metabolizing enzymes (DMEs) in the cell lines can diffe...
ORGANISM(S): Homo sapiens (Human) 
2018-04-18 | PXD008190 | Pride
Hep3b Swath Human liver Huh7 Mrm-hr Proteomics Drug-metabolizing enzymes Hepg2 Protein expression 
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