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ProteomicsA novel non-galactosylated tolerogenic antigen-specific vaccine protects against arthritis via VISTA-expressing regulatory T cells in DRB1*04:01 mice
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, cartilage damage and bone erosion. Despite improvements with the introduction of biological disease-modifying anti-rheumatic drugs (DMARDs), RA remains incurable. Advancements in peptide-based vaccination...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD056818 | Pride
Vaccine Arthritis Mice Immune cells 
ProteomicsArthritis protection conferred by a subset of antibodies to citrullinated proteins in rheumatoid arthritis - macrophage samples
Anti-citrullinated protein antibodies (ACPAs) are one of the hallmarks in rheumatoid arthritis (RA), but the in vivo function remained unclear. To investigate the effects of ACPAs, we expressed monoclonal ACPAs derived from RA patients, and analyzed the functions in mouse models, as well as the reac...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-09 | PXD035177 | Pride
Anti-citrullinated protein antibodies Rheumatoid arthritis Autoimmune 
ProteomicsProteomics to determine metallodrug targets and optimal drug combinations
The FITExP profiling approach was used to identify protein hits from cells incubated with RAPTA-T or RAPTA-EA. Validation experiments with paclitaxel and cisplatin underlined the reliability of the method and hit lists for both test compounds (and?) gave physiologically viable anti-cancer mechanisms...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD005766 | Pride
Drug targets Fitexp Cancer 
ProteomicsArthritis protection conferred by a subset of antibodies to citrullinated proteins in rheumatoid arthritis - human synovium fluids samples
Anti-citrullinated protein antibodies (ACPAs) are one of the hallmarks in rheumatoid arthritis (RA), but the in vivo function remained unclear. To investigate the effects of ACPAs, we expressed monoclonal ACPAs derived from RA patients, and analyzed the functions in mouse models, as well as the reac...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD035180 | Pride
Anti-citrullinated protein antibodies Rheumatoid arthritis Autoimmune 
ProteomicsA peptide-based tolerizing vaccine against autoimmune arthritis directly interacting with antigen-specific T cells
A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. Major hindrances have so far been to select natural regulatory antigen targets and side-effects induced by clustering the T cell receptor (TCR) or activating the costimulatory signa...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-15 | PXD034792 | Pride
Autoimmune arthritis Arthritis Antigen-specific t cells Vaccine 
UnknownA subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis.
Not available
S-EPMC9908943 | biostudies-literature
UnknownA subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils.
Not available
S-EPMC10517938 | biostudies-literature
ProteomicsIon-based Proteome Integrated Solubility Alteration Assay for System-wide Profiling of Protein-Molecule Interactions - full curve data
Unbiased drug target engagement deconvolution and mechanism of action elucidation are major challenges in drug development. Modification-free target engagement methods, such as thermal proteome profiling, have gained increasing popularity over the last several years. However, these methods have limi...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033081 | Pride
Proteomics Mechanism of action Drug target deconvolution Thermal protein profiling Cancer 
ProteomicsRedox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation
PTPN22, a modifier of T cell receptor signaling, and reactive oxygen species are major players in the regulation of chronic autoimmune diseases. As with all protein tyrosine phosphatases the activity of PTPN22 is redox regulated, but if or how such regulation can modulate inflammatory pathways in vi...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-23 | PXD025319 | Pride
Autoimmunity Ptpn22 Reactive oxygen species Lymphocyte signaling 
ProteomicsComprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox proteomics for deconvolution of auranofin targets to ai...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016776 | Pride
Cancer Nfkb2 Mass spectrometry Hct116 Thioredoxin reductase Expression Chordc1 Database A375 Drug Proteomics Resource Rko Chemotherapeutic Auranofin Compound 
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