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ProteomicsIdentification of a collagen marker in urine improves the detection of colorectal liver metastases
Previously, we reported that a combination of a collagen alpha-1(I) natural occurring peptide (NOP) AGPP(-OH)GEAGKP(-OH)GEQGVP(-OH)GDLGAP(-OH)GP (AGP) and serum carcinoembryonic antigen (CEA) has the potential to detect colorectal liver metastases (CRLM). The combined method needs to be adapted to i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-15 | PXD013533 | Pride
Logistic regression model Colon cancer Colorectal cancer Prm Collagen Colorectal liver metastases Mass spectrometry Natural occurring peptides Urine 
ProteomicsIdentification of a collagen marker in urine improves the detection of colorectal liver metastases
Previously, we reported that a combination of a collagen alpha-1(I) natural occurring peptide (NOP) AGPP(-OH)GEAGKP(-OH)GEQGVP(-OH)GDLGAP(-OH)GP (AGP) and serum carcinoembryonic antigen (CEA) has the potential to detect colorectal liver metastases (CRLM). The combined method needs to be adapted to i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-15 | PXD013705 | Pride
Logistic regression model Colon cancer Colorectal cancer Prm Collagen Colorectal liver metastases Mass spectrometry Natural occurring peptides Urine 
ProteomicsIdentification of 4-Hydroxyproline at the Xaa Position in Collagen by Mass Spectrometry
Collagen has a triple helix form, structured by a [-Gly-Xaa-Yaa-] repetition, where Xaa and Yaa are amino acids. This repeating unit can be post-translationally modified by enzymes, where proline is often hydroxylated into hydroxyproline (Hyp). Two Hyp isomers occur in collagen: 4-hydroxyproline (4H...
ORGANISM(S): Homo sapiens (Human) 
2019-03-20 | PXD011784 | Pride
Ab initio Colorectal liver metastasis Mass spectrometry Collagen Ptm Liver Etd Hydroxyproline Posttranslational modification Orbitrap fusion 
ProteomicsDown-regulation of collagen hydroxylation in colorectal liver metastasis
Collagen, a major component of the extracellular matrix, is significantly upregulated in colorectal liver metastasis (CRLM) compared to liver tissue. Expression levels of specific collagen types in CRLM resemble those in colorectal cancer (CRC) and colon tissue. We investigated whether the collagen ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD015015 | Pride
Crlm Liver Human Ptm Crc Collagen Colon Orbitrap fusion 
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