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ProteomicsChikungunya virus phosphoproteomics
SILAC-labeled MRC-5 cells were seeded in 75-cm2 flasks 1 day before infection with CHIKV-LS3 [1] at MOI 5. One hour post infection (h p.i.), the inoculum was removed and replaced with SILAC DMEM containing 2% dialyzed FBS, 0.280 mM arginine, 0.384 mM lysine, 0.5 mM proline, 25 mM HEPES, 2 mM L-Gluta...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD009381 | Pride
Chikungunya virus chikv phosphoproteomics 
MetabolomicsAMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism.
Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism. Yet the contribution of AMP-activated kinase (AMPK), a central energy sensor promoting c...
2024-08-16 | MTBLS10647 | MetaboLights
ProteomicsElucidation of the glycan structure of the b-type flagellin of Pseudomonas aeruginosa PAO1
Flagella are essential for motility and pathogenicity in many bacteria. The main component of the flagellar filament, flagellin, often undergoes post-translational modifications, with glycosylation being a common occurrence. In Pseudomonas aeruginosa PAO1, the b-type flagellin is O-glycosylated with...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-05-07 | PXD056085 | Pride
Glycosylation Mass spectrometry (ms) Proteomics Cell motility Bacteria Pseudomonas 
ProteomicsDevelopment of covalent probes to capture Legionella pneumophila effector enzymes
Upon infection of host cells Legionella pneumophila releases a multitude of effector enzymes into the hosts cytoplasm that hijack a plethora of cellular activities, including the hosts ubiquitination pathways. Effectors belonging to the SidE-family are involved in non-canonical serine phosphoribosyl...
ORGANISM(S): Homo sapiens (Human) Legionella pneumophila subsp. pneumophila Lp02 
2025-05-06 | PXD049797 | Pride
Legionella pneumophila Activity-based probe Ubiquitylation Adp-ribosylation Bacterial infection 
ProteomicsExtracellular vesicles from TGF-β-activated cancer-associated fibroblasts remodel the tumor microenvironment through EV surface-associated proteins
Cancer-associated fibroblasts (CAFs) are a major stromal cell type within the tumor microenvironment (TME). Transforming growth factor-β (TGF-β) is a key cytokine in the TME that activates CAFs, which alters their ability to remodel the extracellular matrix (ECM) and changes their secretome profile....
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD061656 | Pride
Cancer-associated fibroblast Tgf-β Tsg6 Cd8+ t cells Extracellular vesicles Ev surface-associated proteins 
ProteomicscircTBRII(3-6) acts as assembly platform for IGF2BP3 protein and TBRI mRNA to enhance breast cancer cell plasticity
Transforming growth factor (TGF)-β signaling is a key driver to induce epithelial-to-mesenchymal transition (EMT), a process that enhances cancer cell plasticity and metastatic potential. However, the role of circular RNAs (circRNAs) in TGF-β signaling remains largely unexplored. Here, we identify c...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD061218 | Pride
Insulin-like growth factor 2 mrna binding protein 3 Circtbrii(3-6) Epithelial-to-mesenchymal transition Transforming growth factor (tgf)-β 
ProteomicsUveal melanoma cell lines are representative for their tumour, except cell lines Mel285 and Mel290: the odd two out
Purpose: In uveal melanoma (UM) research, several cell lines are used in preclinical studies. Because Mel285 and Mel290 do not harbour typical GNAQ or GNA11 hotspot mutations, we aimed at better classifying them and understanding if we could find genetic causes to explain their protein and mRNA expr...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD051055 | Pride
G protein subunit alpha Mel285 Uveal melanoma Mel290 Cnas 
ProteomicsPromiscuity of peptides presented in HLA-DP molecules from different immunogenicity groups is associated with T-cell cross-reactivity
In the context of HLA-DP-mismatched allogeneic stem cell transplantation, mismatched HLA-DP alleles can provoke profound allo-HLA-DP-specific immune responses from the donor T-cell repertoire leading to graft-versus-leukemia effect and/or graft-versus-host disease in the patient. The magnitude of al...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD030591 | Pride
Allosct Dpc-classification Cd4 t-cell clones Peptidome Hla-dp Cross-reactivity 
UnknownCytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.
Not available
S-EPMC31166 | biostudies-literature
UnknownA transcriptomic based deconvolution framework for assessing differentiation stages and drug responses of AML.
Not available
S-EPMC11102519 | biostudies-literature
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