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UnknownIdentification of novel candidate genes associated with cleft lip and palate using array comparative genomic hybridisation.

Aim and method

We analysed DNA samples isolated from individuals born with cleft lip and cleft palate to identify deletions and duplications of candidate gene loci using array comparative genomic hybridisation (array-CGH).

Results

Of 83 syndromic cases analysed we identified one subje...
S-EPMC3732463 | biostudies-literature
UnknownSialic acid-modified der p 2 allergen exerts immunomodulatory effects on human PBMCs.

Background

House dust mite extract-based allergen immunotherapy (AIT) to treat house dust mite allergy is substantially effective but still presents some safety and efficacy concerns that warrant improvement. Several major allergen-based approaches to increase safety and efficacy of AIT have...
S-EPMC10770723 | biostudies-literature
Proteomicshuman MS Lesions ABPP - foamy microglia link oxylipins to disease progression in multiple sclerosis
In this study lesions from human MS brains and controls were isolated and analyzed by Activity-based protein profiling using fluorophosphonate- and beta-lacton probes to enrich active enzymes from the samples. these were subsequently analyzed by LC/MS-MS.
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD056899 | Pride
Multiple sclerosis Activity-based protein profiling Serine hydrolase Lesions Brain Chemical proteomics Fluorophosphonate 
UnknownRedox-dependent regulation of epidermal growth factor receptor signaling.
Tyrosine phosphorylation-dependent cell signaling represents a unique feature of multicellular organisms, and is important in regulation of cell differentiation and specialized cell functions. Multicellular organisms also contain a diverse family of NADPH oxidases (NOXs) that have been closely linke...
S-EPMC4710793 | biostudies-literature
ProteomicsABPP using chemical proteomics in Alzheimer's Disease and Resilience
pulldown on enzymes targeted by serine hydrolase probes tetrahydrolipstatin-biotin and fluorophosphonate biotin probe in lysates from the frontal cortex of 36 patients (12 conrol, 12 Alzheimer's, 12 Resilient). below is the abstract: Alzheimer’s Disease (AD) is the most common form of dementia. Wh...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD057993 | Pride
Abpp Alzheimer's disease Serine hydrolases 
UnknownThe NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling.
The epidermal growth factor receptor (EGFR) plays a critical role in regulating airway epithelial homeostasis and responses to injury. Activation of EGFR is regulated by redox-dependent processes involving reversible cysteine oxidation by reactive oxygen species (ROS) and involves both ligand-depend...
S-EPMC5087744 | biostudies-literature
UnknownDysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer.
Lung cancers are frequently characterized by inappropriate activation of epidermal growth factor receptor (EGFR)-dependent signaling and epigenetic silencing of the NADPH oxidase (NOX) enzyme DUOX1, both potentially contributing to worse prognosis. Based on previous findings linking DUOX1 with redox...
S-EPMC6425021 | biostudies-literature
UnknownAirway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses.

Background

The IL-1 family member IL-33 plays a critical role in type 2 innate immune responses to allergens and is an important mediator of allergic asthma. The mechanisms by which allergens provoke epithelial IL-33 secretion are still poorly understood.

Objective

Based on previous f...
S-EPMC4860024 | biostudies-literature
UnknownCross-Cultural Comparison of Nonopioid and Multimodal Analgesic Prescribing in Orthopaedic Trauma.

Background

After musculoskeletal injury, US providers prescribe opioids more frequently and at higher dosages than prescribers in the Netherlands and Haiti; however, the extent of variation in nonopioid analgesic prescribing is unknown. The aim of our study was to evaluate how nonopioid pres...
S-EPMC7434039 | biostudies-literature
ProteomicsEBV latent nuclear antigen EBNA3A modulates IRF3-dependent IFNβ expression
Epstein-Barr virus (EBV) persistently infects over 90% of the human population and is the causative agent of infectious mononucleosis and human cancers. For the establishment of life-long infection, EBV tampers with the induction of type I interferon (IFN I)-dependent antiviral immunity in the host....
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD038572 | Pride
Immune evasion Viral protein Irf3 Proximity labeling Ifn i P300 Herpesvirus Viral immunology 
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