The polymorphisms of ANXA6 influence head and neck cancer susceptibility in the Chinese Han population.

ABSTRACT:

Background

Head and neck cancer (HNC) is the sixth most common malignant tumor worldwide and imposes a serious economic burden on society and individuals. Annexin has been implicated in multiple functions which are essential in HNC development, including cell proliferation, apoptosis, metastasis, and invasion. This study focused on the linkage between ANXA6 variants and HNC susceptibility in Chinese people.

Methods

Eight SNPs in ANXA6 from 139 HNC patients and 135 healthy controls were genotyped by the Agena MassARRAY platform. The correlation of SNPs with HNC susceptibility was evaluated using odds ratio and 95% confidence interval calculated by logistic regression using PLINK 1.9.

Results

Overall analysis results demonstrated that rs4958897 was correla

SUBMITTER: Xiong W 

PROVIDER: S-EPMC10043323 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature