Comparison Between ¹⁸F-Florapronol and ¹⁸F-Florbetaben Imaging in Patients With Cognitive Impairment.

ABSTRACT:

Background and purpose

To determine the imaging characteristics and cutoff value of ¹⁸F-florapronol (FC119S) quantitative analysis for detecting β-amyloid positivity and Alzheimer's disease (AD), we compared the findings of FC119S and ¹⁸F-florbetaben (FBB) positron-emission tomography (PET) in patients with cognitive impairment.

Methods

We prospectively enrolled 35 patients with cognitive impairment who underwent FBB-PET, FC119S-PET, and brain magnetic resonance imaging. We measured global and vertex-wise standardized uptake value ratios (SUVRs) using a surface-based method with the cerebellar gray matter as reference. Optimal global FC119S SUVR cutoffs were determined using receiver operating characteristic curves for β-amyloid positivity based on the

SUBMITTER: Baik K 

PROVIDER: S-EPMC10169926 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature