Exploring the Causality Between Body Mass Index and Sepsis: A Two-Sample Mendelian Randomization Study.

ABSTRACT: Objective: Observational epidemiological studies have shown a link between obesity and sepsis, but any causal relationship is not clear. Our study aimed to explore the correlation and causal relationship between body mass index and sepsis by a two-sample Mendelian randomization (MR). Methods: In large sample genome-wide association studies, single-nucleotide polymorphisms related to body mass index were screened as instrumental variables. Three MR methods, MR-Egger regression, weighted median estimator, and inverse variance-weighted, were used to evaluate the causal relationship between body mass index and sepsis. Odds ratio (OR) and 95% confidence interval (CI) were used as the evaluation index of causality, and sensitivity analyses were conducted to assess pleiotropy and in

SUBMITTER: Wang J 

PROVIDER: S-EPMC10186272 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature