[⁶⁸Ga]Ga-NODAGA-E[(cRGDyK)]₂ angiogenesis PET following myocardial infarction in an experimental rat model predicts cardiac functional parameters and development of heart failure.

ABSTRACT:

Background

Angiogenesis has increasingly been a target for imaging and treatment over the last decade. The integrin α_vβ₃ is highly expressed in cells during angiogenesis and are therefore a promising target for imaging. In this study, we aimed to investigate the PET tracer [⁶⁸Ga]Ga-RGD as a marker of angiogenesis following MI and its ability to predict cardiac functional parameters.

Methods

First, the real-time interaction between [⁶⁸Ga]Ga-RGD and integrin α_vβ₃ was investigated using surface plasmon resonance (SPR). Second, an animal study was performed to investigate the [⁶⁸Ga]Ga-RGD uptake in the infarcted area after one and four weeks following MI in a rat model (MI = 68, sham surgery = 36). Fina

SUBMITTER: Bentsen S 

PROVIDER: S-EPMC10558373 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature