Causal role of immune cells in alopecia areata: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous research has highlighted an association between alopecia areata (AA) and the collapse of hair follicle immune privilege, however, the causal linkage to specific immune cell traits remains to be elucidated. This study aimed to investigate the causal influence of immune cell traits on AA utilizing a two-sample Mendelian randomization (MR) approach.

Methods

Leveraging GWAS summary statistics of 731 immunological traits (n = 3757) and AA data (n = 211,428), MR analyses were conducted employing inverse-variance weighted (IVW), weighted median, and MR-Egger regression methodologies. Sensitivity analyses were undertaken using Cochran's Q test, MR-Egger intercept test, and MR-PRESSO analysis. A reverse MR analysis was performed for immune cell traits identified i

SUBMITTER: Xu W 

PROVIDER: S-EPMC10788640 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature