Mendelian randomization study highlights hypothyroidism as a causal determinant of alopecia areata.

ABSTRACT:

Background

Although observational studies have found an association between hypothyroidism and alopecia areata, the causality of this relationship remains unclear.

Objectives

This study aimed to investigate the genetic variants associated with hypothyroidism and their potential impact on the risk of developing alopecia areata.

Methods

genome-wide association study summary statistics for hypothyroidism (30,155 cases and 379,986 controls) and alopecia areata (289 cases and 211,139 controls) were obtained from the IEU OpenGwas project. The inverse variance-weighted method was used as the primary analysis method to evaluate the causality between hypothyroidism and alopecia areata, supplemented by the weighted median, MR-Egger, simple mode and weighted mode. Furthermore, t

SUBMITTER: Zheng XY 

PROVIDER: S-EPMC10826415 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature