Cbl-b mitigates the responsiveness of naive CD8⁺ T cells that experience extensive tonic T cell receptor signaling.

ABSTRACT: Naive T cells experience tonic T cell receptor (TCR) signaling in response to self-antigens presented by major histocompatibility complex (MHC) in secondary lymphoid organs. We investigated how relatively weak or strong tonic TCR signals influence naive CD8⁺ T cell responses to stimulation with foreign antigens. The heterogeneous expression of Nur77-GFP, a transgenic reporter of tonic TCR signaling, in naive CD8⁺ T cells suggests variable intensities or durations of tonic TCR signaling. Although the expression of genes associated with acutely stimulated T cells was increased in Nur77-GFP^HI cells, these cells were hyporesponsive to agonist TCR stimulation compared with Nur77-GFP^LO cells. This hyporesponsiveness manifested as diminished activation

SUBMITTER: Eggert J 

PROVIDER: S-EPMC10897907 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature