Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults.

ABSTRACT:

Introduction

The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults.

Methods

PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship.

Results

PA was not associated with brain Aβ at baseline (β = -0.001, p = 0.72) or over time (β = -0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over tim

SUBMITTER: Slee MG 

PROVIDER: S-EPMC10917015 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature