Deciphering the function of Com_YlbF domain-containing proteins in <i>Staphylococcus aureus</i>.

ABSTRACT: The Com_YlbF domain-containing proteins inhibit sporulation, competition, and biofilm formation by affecting the activity of ribonuclease RNase-Y in Bacillus subtilis. Similar Com_YlbF proteins are found in Staphylococcus aureus, but their function is yet to be determined. This study investigates the role of Com_YlbF domain-containing proteins (Qrp/YheA, YmcA, and YlbF) in S. aureus by evaluating the impact of qrp/yheA, ymcA, and ylbF gene deletion on biofilm formation, PIA/PNAG production, and hemolytic capacity. It was found that deletion of the three qrp/yheA, ymcA, and ylbF genes in S. aureus produced a decrease in biofilm formation, a slight decrease in PIA/PNAG production, and a decrease in its hemolytic capacity.

SUBMITTER: Corredor-Rozo Z-L 

PROVIDER: S-EPMC12445100 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature