Association of lipoprotein-associated phospholipase A₂ and risk of incident atrial fibrillation: Findings from 3 cohorts.

ABSTRACT:

Background

Multiple prospective studies have established an association between inflammation and higher risk of atrial fibrillation (AF), but the association between lipoprotein-associated phospholipase A₂ (Lp-PLA₂) mass and activity and incident AF has not been extensively evaluated.

Methods

Using data from 10,794 Atherosclerosis Risk In Communities (ARIC) study participants aged 53-75 years, 5,181 Cardiovascular Health Study (CHS) participants aged 65 to 100 years, and 5,425 Multi-Ethnic Study of Atherosclerosis (MESA) participants aged 45-84 years, we investigated the association between baseline Lp-PLA₂ levels and the risk of developing AF. Incident AF was identified in each cohort by follow-up visit electrocardiograms, hospital discharge

SUBMITTER: Garg PK 

PROVIDER: S-EPMC5860682 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature