Hyperpolarised ¹³C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.

ABSTRACT: Hyperpolarised magnetic resonance imaging (HP ¹³C-MRI) is an emerging clinical technique to detect [1-¹³C]lactate production in prostate cancer (PCa) following intravenous injection of hyperpolarised [1-¹³C]pyruvate. Here we differentiate clinically significant PCa from indolent disease in a low/intermediate-risk population by correlating [1-¹³C]lactate labelling on MRI with the percentage of Gleason pattern 4 (%GP4) disease. Using immunohistochemistry and spatial transcriptomics, we show that HP ¹³C-MRI predominantly measures metabolism in the epithelial compartment of the tumour, rather than the stroma. MRI-derived tumour [1-¹³C]lactate labelling correlated with epithelial mRNA expression of the enzyme lactate dehydrogenas

SUBMITTER: Sushentsev N 

PROVIDER: S-EPMC8786834 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature