Periosteal CD68⁺ F4/80⁺ Macrophages Are Mechanosensitive for Cortical Bone Formation by Secretion and Activation of TGF-β1.

ABSTRACT: Mechanical force regulates bone density, modeling, and homeostasis. Substantial periosteal bone formation is generated by external mechanical stimuli, yet its mechanism is poorly understood. Here, it is shown that myeloid-lineage cells differentiate into subgroups and regulate periosteal bone formation in response to mechanical loading. Mechanical loading on tibiae significantly increases the number of periosteal myeloid-lineage cells and the levels of active transforming growth factor β (TGF-β), resulting in cortical bone formation. Knockout of Tgfb1 in myeloid-lineage cells attenuates mechanical loading-induced periosteal bone formation in mice. Moreover, CD68⁺ F4/80⁺ macrophages, a subtype of myeloid-lineage cells, express and activate TGF-β1 for recruitment of ost

SUBMITTER: Deng R 

PROVIDER: S-EPMC8787385 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature